Rio M C, Bellocq J P, Gairard B, Koehl C, Renaud R, Chambon P
L.G.M.E. du CNRS et U. 184 de l'INSERM, Institut de Chimie Biologique, Faculté de Médecine, Strasbourg, France.
Biochimie. 1988 Jul;70(7):961-8. doi: 10.1016/0300-9084(88)90238-6.
The hormone-dependence of some human breast cancers is well recognized. However, the molecular mechanisms responsible for the growth stimulation of these cancers by oestrogens are still poorly understood. With the hope of elucidating these mechanisms, we have recently cloned and studied the structure-function relationship of the human oestrogen and progestin receptors, and also undertaken a study aimed at characterizing genes whose expression is controlled by oestrogens in hormone-dependent breast cancers. We review here our findings concerning one of these genes and its expression products, the pS2 gene. We discuss also whether a systematic determination of pS2 gene expression in breast cancer biopsies could be useful to establish a new biochemical classification of these cancers which may be useful to improve the diagnosis of hormone-dependent cancers.
某些人类乳腺癌的激素依赖性已得到充分认识。然而，雌激素刺激这些癌症生长的分子机制仍知之甚少。怀着阐明这些机制的希望，我们最近克隆并研究了人类雌激素和孕激素受体的结构-功能关系，还开展了一项旨在鉴定激素依赖性乳腺癌中受雌激素调控表达的基因的研究。在此，我们综述关于其中一个基因及其表达产物pS2基因的研究结果。我们还讨论了系统测定乳腺癌活检组织中pS2基因表达是否有助于建立这些癌症的新生化分类，这可能有助于改善激素依赖性癌症的诊断。
