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尼群地平治疗哮喘患者。

Nitrendipine therapy in asthmatic subjects.

作者信息

Mulloy E M, Cormie P, Harvey J, Marley J E

机构信息

Ham Green Hospital, Pill, Bristol.

出版信息

Br J Clin Pharmacol. 1990 Sep;30(3):493-5. doi: 10.1111/j.1365-2125.1990.tb03804.x.

DOI:10.1111/j.1365-2125.1990.tb03804.x
PMID:2223429
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1368156/
Abstract

Nitrendipine was given to eight patients with chronic stable asthma prior to a histamine challenge study and compared in a double-blind cross-over fashion with placebo. There were no significant differences in either the bronchoconstrictor effects of histamine, or in oxygen saturation during the histamine challenges, suggesting that nitrendipine should be safely tolerated if used to treat hypertension in patients with airflow obstruction.

摘要

在一项组胺激发试验前，给八名慢性稳定型哮喘患者服用尼群地平，并以双盲交叉方式与安慰剂进行比较。在组胺激发试验期间，组胺的支气管收缩效应或血氧饱和度均无显著差异，这表明如果用于治疗气流阻塞患者的高血压，尼群地平应能安全耐受。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/57ed/1368156/43c7f5c29447/brjclinpharm00067-0148-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/57ed/1368156/43c7f5c29447/brjclinpharm00067-0148-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/57ed/1368156/43c7f5c29447/brjclinpharm00067-0148-a.jpg

相似文献

1
Nitrendipine therapy in asthmatic subjects.尼群地平治疗哮喘患者。
Br J Clin Pharmacol. 1990 Sep;30(3):493-5. doi: 10.1111/j.1365-2125.1990.tb03804.x.
2
Studies of the effects of inhaled magnesium on airway reactivity to histamine and adenosine monophosphate in asthmatic subjects.吸入镁对哮喘患者气道对组胺和单磷酸腺苷反应性影响的研究。
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J Cardiovasc Pharmacol. 1991;18 Suppl 1:S48-50.
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The protective effect of a beta 2 agonist against excessive airway narrowing in response to bronchoconstrictor stimuli in asthma and chronic obstructive lung disease.β2 激动剂对哮喘和慢性阻塞性肺疾病中支气管收缩刺激引起的气道过度狭窄的保护作用。
Thorax. 1991 Jan;46(1):9-14. doi: 10.1136/thx.46.1.9.
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本文引用的文献

1
A calcium antagonist, nifedipine, modifies exercise-induced asthma.钙拮抗剂硝苯地平可改善运动诱发的哮喘。
Thorax. 1981 Oct;36(10):726-30. doi: 10.1136/thx.36.10.726.
2
Nitrendipine and other calcium entry blockers (calcium antagonists) in hypertension.尼群地平及其他钙通道阻滞剂（钙拮抗剂）治疗高血压
Fed Proc. 1983 Feb;42(2):196-200.
3
Experience with nitrendipine--a new calcium antagonist--in hypertension.尼群地平——一种新型钙拮抗剂——治疗高血压的经验。
J Cardiovasc Pharmacol. 1982;4 Suppl 3:S387-91. doi: 10.1097/00005344-198200433-00025.
4
Effect of nifedipine on arterial hypoxaemia occurring after methacholine challenge in asthma.硝苯地平对哮喘患者乙酰甲胆碱激发试验后发生的动脉低氧血症的影响。
Thorax. 1986 Jun;41(6):468-72. doi: 10.1136/thx.41.6.468.
5
Nitrendipine and atenolol: comparison and combination in the treatment of arterial hypertension.尼群地平和阿替洛尔：治疗动脉高血压的比较与联合应用
Arzneimittelforschung. 1985;35(4):727-9.
6
A comparison of the haemodynamic effects of nifedipine, nisoldipine and nitrendipine in man.
Eur J Clin Pharmacol. 1986;30(4):393-7. doi: 10.1007/BF00607950.
7
Treatment of hypertensive urgencies and emergencies with nitrendipine, nifedipine, and clonidine: effect on blood pressure and heart rate.使用尼群地平、硝苯地平和可乐定治疗高血压急症和亚急症：对血压和心率的影响。
J Cardiovasc Pharmacol. 1988;12 Suppl 4:S154-6. doi: 10.1097/00005344-198806124-00035.
8
Bronchial reactivity to inhaled histamine: a method and clinical survey.支气管对吸入组胺的反应性：一种方法及临床调查。
Clin Allergy. 1977 May;7(3):235-43. doi: 10.1111/j.1365-2222.1977.tb01448.x.