Andrén L, Hansson L, Orö L, Ryman T
J Cardiovasc Pharmacol. 1982;4 Suppl 3:S387-91. doi: 10.1097/00005344-198200433-00025.
The antihypertensive effect of 20 mg of nitrendipine (BAY e 5009) was compared with that of 40 mg, administered orally once daily to 12 patients with essential hypertension (WHO I-II). The study was designed as a double-blind, within-patient comparison. The present results indicate that nitrendipine has a significant antihypertensive effect both at 20 and 40 mg as compared to placebo. There was no significant change in heart rate with 20 mg of nitrendipine, whereas there was a significant increase in heart rate after the first dose of 40 mg. Nitrendipine in dosages of 20 mg and 40 mg daily was equally effective as regards the antihypertensive effect. This applies both to the early response (first day) and the late response (3 weeks). Side effects were common in the 40-mg treatment group, but rare in the 20-mg group; only one patient had headache (three times) during the 3-week treatment period. It can be concluded that in mild hypertension, treatment with 20 mg of nitrendipine once daily constitutes an effective antihypertensive therapy. In more severe cases of hypertension, however, combination treatment with beta-blockers, for example, and/or repeated daily administration of nitrendipine ought to be investigated.
将20毫克尼群地平（BAY e 5009）的降压效果与40毫克尼群地平进行比较，对12例原发性高血压（WHO I-II级）患者每日口服给药一次。该研究设计为双盲、患者自身对照研究。目前的结果表明，与安慰剂相比，20毫克和40毫克尼群地平均具有显著的降压效果。服用20毫克尼群地平后心率无显著变化，而服用首剂40毫克后心率显著增加。每日服用20毫克和40毫克尼群地平的降压效果相同。这在早期反应（第一天）和晚期反应（3周）中均适用。副作用在40毫克治疗组中常见，但在20毫克组中罕见；在3周治疗期间，只有1例患者出现头痛（3次）。可以得出结论，在轻度高血压中，每日一次服用20毫克尼群地平构成有效的降压治疗。然而，在更严重的高血压病例中，应研究例如与β受体阻滞剂联合治疗和/或每日重复给药尼群地平。
