铁(III)催化的炔烃、CH2Cl2 和胺的三组分偶联反应高效合成丙炔胺。
Efficient iron(III)-catalyzed three-component coupling reaction of alkynes, CH2Cl2 and amines to propargylamines.
机构信息
State Key Laboratory and Institute of Elemento-Organic Chemistry, Nankai University, Tianjin 300071, People's Republic of China.
出版信息
Chem Commun (Camb). 2012 Feb 14;48(14):2024-6. doi: 10.1039/c2cc17616e. Epub 2012 Jan 11.
PMID:22234426
Abstract
An iron(III)-catalyzed three-component coupling reaction of alkynes, CH(2)Cl(2) and amines was developed for facile synthesis of propargylamines. Preliminary mechanism investigation using in situ FT-IR reveals that the crucial Fe-acetylide intermediate could be formed through C-H bond activation of alkynes thanks to cooperative effect of FeCl(3) and 1,1,3,3-tetramethylguanidine.
摘要
发展了一种铁(III)催化的炔烃、CH(2)Cl(2)和胺的三组分偶联反应，用于方便地合成炔丙胺。使用原位傅里叶变换红外光谱法进行的初步机理研究表明，关键的 Fe-炔基中间体可以通过炔烃的 C-H 键活化形成，这要归功于 FeCl(3)和 1,1,3,3-四甲基胍的协同作用。
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