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黄芩乙醇提取物对阴茎海绵体平滑肌松弛的影响。

Effect of an Ethanol Extract of Scutellaria baicalensis on Relaxation in Corpus Cavernosum Smooth Muscle.

机构信息

Professional Graduate School of Oriental Medicine and College of Oriental Medicine, Wonkwang University, Iksan, Jeonbuk 570-749, Republic of Korea.

出版信息

Evid Based Complement Alternat Med. 2012;2012:148929. doi: 10.1155/2012/148929. Epub 2011 Dec 22.

DOI:10.1155/2012/148929
PMID:22235229
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3253488/
Abstract

Aims of study. The aim of the present study was to investigate whether an ethanol extract of Scutellaria baicalensis (ESB) relaxes penile corpus cavernosum muscle in organ bath experiments. Materials and methods. Changes in tension of cavernous smooth muscle strips were determined by penile strip chamber model and in penile perfusion model. Isolated endothelium-intact rabbit corpus cavernosum was precontracted with phenylephrine (PE) and then treated with ESB. Results. ESB relaxed penile smooth muscle in a dose-dependent manner, and this was inhibited by pre-treatment with N(G)-nitro-l-arginine methyl ester (l-NAME), a nitric oxide (NO) synthase inhibitor, and 1H-[1, 2, 4]-oxadiazolo-[4,3-α]-quinoxalin-1-one (ODQ), a soluble guanylyl cyclase (sGC) inhibitor. ESB-induced relaxation was significantly attenuated by pretreatment with tetraethylammonium (TEA), a nonselective K(+) channel blocker, and charybdotoxin, a selective Ca(2+)-dependent K(+) channel inhibitor. ESB increased the cGMP levels of rabbit corpus cavernosum in a concentration-dependent manner without changes in cAMP levels. In a perfusion model of penile tissue, ESB also relaxed penile corpus cavernosum smooth muscle in a dose-dependent manner. Conclusion. Taken together, these results suggest that ESB relaxed rabbit cavernous smooth muscle via the NO/cGMP system and Ca(2+)-sensitive K(+) channels in the corpus cavernosum.

摘要

目的

本研究旨在探讨黄芩乙醇提取物（ESB）是否通过器官浴实验松弛阴茎海绵体肌肉。

材料与方法

采用阴茎带腔模型和阴茎灌注模型，测定海绵体平滑肌条张力的变化。用苯肾上腺素（PE）预收缩完整内皮兔阴茎海绵体，然后用 ESB 处理。

结果

ESB 呈剂量依赖性松弛阴茎平滑肌，这种作用被一氧化氮合酶抑制剂 N(G)-硝基-l-精氨酸甲酯（l-NAME）和可溶性鸟苷酸环化酶（sGC）抑制剂 1H-[1,2,4]-恶二唑-[4,3-α]-喹喔啉-1-酮（ODQ）预处理所抑制。用非选择性钾通道阻滞剂四乙铵（TEA）和选择性钙依赖性钾通道抑制剂蟾毒灵预处理可显著减弱 ESB 诱导的松弛作用。ESB 以浓度依赖的方式增加兔阴茎海绵体的 cGMP 水平，而 cAMP 水平没有变化。在阴茎组织灌注模型中，ESB 也呈剂量依赖性松弛阴茎海绵体平滑肌。

结论

综上所述，这些结果表明 ESB 通过阴茎海绵体中的 NO/cGMP 系统和 Ca2+敏感的 K+通道松弛兔海绵体平滑肌。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8d4a/3253488/e96ac00a49a8/ECAM2012-148929.007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8d4a/3253488/92288e77c7b8/ECAM2012-148929.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8d4a/3253488/c07a6b94c751/ECAM2012-148929.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8d4a/3253488/cbbf7cef2a42/ECAM2012-148929.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8d4a/3253488/51e981a4fed3/ECAM2012-148929.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8d4a/3253488/2f1a91617a28/ECAM2012-148929.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8d4a/3253488/66dccdf8fa7b/ECAM2012-148929.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8d4a/3253488/e96ac00a49a8/ECAM2012-148929.007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8d4a/3253488/92288e77c7b8/ECAM2012-148929.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8d4a/3253488/c07a6b94c751/ECAM2012-148929.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8d4a/3253488/cbbf7cef2a42/ECAM2012-148929.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8d4a/3253488/51e981a4fed3/ECAM2012-148929.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8d4a/3253488/2f1a91617a28/ECAM2012-148929.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8d4a/3253488/66dccdf8fa7b/ECAM2012-148929.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8d4a/3253488/e96ac00a49a8/ECAM2012-148929.007.jpg

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