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在牛体内，前列腺素 F（2α）诱导黄体溶解过程中，黄体中多形核白细胞迅速积累。

Rapid accumulation of polymorphonuclear neutrophils in the Corpus luteum during prostaglandin F(2α)-induced luteolysis in the cow.

机构信息

Graduate School of Animal and Food Hygiene, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Japan.

出版信息

PLoS One. 2012;7(1):e29054. doi: 10.1371/journal.pone.0029054. Epub 2012 Jan 3.

DOI:10.1371/journal.pone.0029054
PMID:22235260
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3250407/
Abstract

Prostaglandin F(2α) (PGF(2α)) induces luteolysis within a few days in cows, and immune cells increase in number in the regressing corpus luteum (CL), implying that luteolysis is an inflammatory-like immune response. We investigated the rapid change in polymorphonuclear neutrophil (PMN) numbers in response to PGF(2α) administration as the first cells recruited to inflammatory sites, together with mRNA of interleukin-8 (IL-8: neutrophil chemoattractant) and P-selectin (leukocyte adhesion molecule) in the bovine CL. CLs were collected by ovariectomy at various times after PGF(2α) injection. The number of PMNs was increased at 5 min after PGF(2α) administration, whereas IL-8 and P-selectin mRNA increased at 30 min and 2 h, respectively. PGF(2α) directly stimulated P-selectin protein expression at 5-30 min in luteal endothelial cells (LECs). Moreover, PGF(2α) enhanced PMN adhesion to LECs, and this enhancement by PGF(2α) was inhibited by anti-P-selectin antibody, suggesting that P-selectin expression by PGF(2α) is crucial in PMN migration. In conclusion, PGF(2α) rapidly induces the accumulation of PMNs into the bovine CL at 5 min and enhances PMN adhesion via P-selectin expression in LECs. It is suggested that luteolytic cascade by PGF(2α) may involve an acute inflammatory-like response due to rapidly infiltrated PMNs.

摘要

前列腺素 F(2α)（PGF(2α)）在奶牛体内几天内就会导致黄体溶解，并且在退化的黄体（CL）中免疫细胞数量增加，这表明黄体溶解是一种类似炎症的免疫反应。我们研究了多形核中性粒细胞（PMN）数量对 PGF(2α)给药的快速变化，因为 PMN 是最早募集到炎症部位的细胞之一，同时还研究了牛 CL 中白细胞介素-8（IL-8：PMN 趋化因子）和 P 选择素（白细胞黏附分子）的 mRNA。PGF(2α)注射后，通过卵巢切除术在不同时间收集 CL。PGF(2α)给药后 5 分钟 PMN 数量增加，而 IL-8 和 P 选择素 mRNA 分别在 30 分钟和 2 小时增加。PGF(2α)可直接在黄体内皮细胞（LEC）中刺激 P 选择素蛋白表达，时间在 5-30 分钟。此外，PGF(2α)增强了 PMN 对 LEC 的黏附作用，而 PGF(2α)的这种增强作用被抗 P 选择素抗体抑制，表明 P 选择素表达对 PMN 迁移至关重要。综上所述，PGF(2α)可在 5 分钟内迅速诱导 PMN 聚集到牛 CL 中，并通过 LEC 中的 P 选择素表达增强 PMN 黏附作用。这表明 PGF(2α)引起的黄体溶解级联反应可能涉及到 PMN 迅速浸润引起的急性类似炎症的反应。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/368a/3250407/3acf015d75d6/pone.0029054.g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/368a/3250407/9fc95e46408b/pone.0029054.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/368a/3250407/68f2fa66a734/pone.0029054.g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/368a/3250407/515158483b1c/pone.0029054.g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/368a/3250407/d2912821f67a/pone.0029054.g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/368a/3250407/d16c19a3fa28/pone.0029054.g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/368a/3250407/9fa9e375bf8e/pone.0029054.g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/368a/3250407/3acf015d75d6/pone.0029054.g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/368a/3250407/9fc95e46408b/pone.0029054.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/368a/3250407/68f2fa66a734/pone.0029054.g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/368a/3250407/515158483b1c/pone.0029054.g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/368a/3250407/d2912821f67a/pone.0029054.g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/368a/3250407/d16c19a3fa28/pone.0029054.g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/368a/3250407/9fa9e375bf8e/pone.0029054.g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/368a/3250407/3acf015d75d6/pone.0029054.g007.jpg

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