鞘内注射131I放射性标记单克隆抗体治疗肿瘤性脑膜炎。
Intrathecal administration of 131I radiolabelled monoclonal antibody as a treatment for neoplastic meningitis.
作者信息
Moseley R P, Davies A G, Richardson R B, Zalutsky M, Carrell S, Fabre J, Slack N, Bullimore J, Pizer B, Papanastassiou V
机构信息
Department of Neurosurgery, Frenchay Hospital, Bristol, UK.
出版信息
Br J Cancer. 1990 Oct;62(4):637-42. doi: 10.1038/bjc.1990.345.
Abstract
Fifteen patients with neoplastic meningitis received a single intrathecal injection of between 11 and 60 mCi of a 131I radiolabelled monoclonal antibody (MoAb), chosen for its immunoreactivity to tumour. Major toxicity was manifest as nausea, vomiting and headache (7/15 patients), reversible bone marrow suppression (3/8 patients) and seizures (2/15 patients). Nine patients were evaluable for either a tumour or clinical response. Six of these demonstrated an event-free response that was maintained for periods of between 7 and 26 months.
摘要
15例肿瘤性脑膜炎患者接受了鞘内注射11至60毫居里的131I放射性标记单克隆抗体（MoAb），该抗体因其对肿瘤的免疫反应性而被选用。主要毒性表现为恶心、呕吐和头痛（7/15例患者）、可逆性骨髓抑制（3/8例患者）和癫痫发作（2/15例患者）。9例患者可评估肿瘤或临床反应。其中6例表现出无事件反应，持续时间为7至26个月。
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