利用尿中多胺排泄模式预测上皮性卵巢癌患者对化疗的反应。
Predicting response to chemotherapy for patients with epithelial ovarian cancer using urinary polyamine excretion patterns.
作者信息
Lawton F G, Griffin M, Slack J A, Blackledge G
机构信息
Academic Department of Obstetrics and Gynaecology, University of Birmingham, UK.
出版信息
Br J Cancer. 1990 Oct;62(4):692-4. doi: 10.1038/bjc.1990.359.
Urinary polyamine (UPA) excretion patterns were measured in 39 patients with clinically evaluable epithelial ovarian cancer immediately before they were treated with a cycle of chemotherapy and 24-48 h after chemotherapy to ascertain if changes in UPA excretion patterns correlated with eventual response to treatment. Almost all of the 19 patients who responded to chemotherapy had a rise in the excretion of all UPA fractions after treatment while most patients with chemoresistant cancer showed only an increase in the excretion of the putrescine and spermine fractions. However, a two-fold increase in excretion of the spermidine fractions occurred exclusively in patients who would eventually respond to chemotherapy. This phenomenon was not seen in patients with chemoresistant cancer. If, 48 h after chemotherapy, a patient with epithelial ovarian cancer does not show at least a doubling of the urinary levels of spermidine, acetylspermidine or total polyamine excretion that chemotherapy should be stopped since it is unlikely to be effective.
对39例临床可评估的上皮性卵巢癌患者在接受化疗周期前及化疗后24 - 48小时测量尿多胺（UPA）排泄模式，以确定UPA排泄模式的变化是否与最终治疗反应相关。几乎所有19例对化疗有反应的患者在治疗后所有UPA组分的排泄量均增加，而大多数化疗耐药的癌症患者仅腐胺和精胺组分的排泄量增加。然而，亚精胺组分排泄量增加两倍仅发生在最终对化疗有反应的患者中。化疗耐药的癌症患者未出现这种现象。如果上皮性卵巢癌患者在化疗后48小时尿中亚精胺、乙酰亚精胺或总多胺排泄量未至少增加一倍，则应停止化疗，因为化疗不太可能有效。
Zotero 插件