葡萄膜黑色素瘤细胞系的遗传和分子特征。
Genetic and molecular characterization of uveal melanoma cell lines.
机构信息
Human Oncology and Pathogenesis Program, Memorial Sloan-Kettering Comprehensive Cancer Center, New York, NY, USA.
出版信息
Pigment Cell Melanoma Res. 2012 Mar;25(2):182-7. doi: 10.1111/j.1755-148X.2012.00971.x. Epub 2012 Feb 2.
Abstract
The recent identification of frequent activating mutations in GNAQ or GNA11 in uveal melanoma provides an opportunity to better understand the pathogenesis of this melanoma subtype and to develop rational therapeutics to target the cellular effects mediated by these mutations. Cell lines from uveal melanoma tumors are an essential tool for these types of analyses. We report the mutation status of relevant melanoma genes, expression levels of proteins of interest, and DNA fingerprinting of a panel of uveal melanoma cell lines used in the research community.
摘要
最近在葡萄膜黑素瘤中频繁发现 GNAQ 或 GNA11 的激活突变，这为更好地了解这种黑素瘤亚型的发病机制以及开发针对这些突变介导的细胞效应的合理治疗方法提供了机会。葡萄膜黑素瘤肿瘤的细胞系是进行此类分析的重要工具。我们报告了在研究界中使用的一组葡萄膜黑素瘤细胞系的相关黑素瘤基因的突变状态、感兴趣蛋白的表达水平以及 DNA 指纹图谱。
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