Charteris D G, Lee W R
Princess Alexandra Eye Pavilion, Royal Infirmary, Edinburgh.
Br J Ophthalmol. 1990 Nov;74(11):688-93. doi: 10.1136/bjo.74.11.688.
A pathological study was performed on the necropsy eyes of a 59-year old-woman who had suffered for nine years from multifocal posterior uveitis. The disease had been controlled by steroid therapy with good preservation of visual function. Extensive investigation did not reveal the aetiology. On macroscopic examination numerous focal lesions with various degrees of pigmentation were observed scattered across the fundi. These lesions were studied by light and electron microscopy and immunohistochemistry. There was ongoing chorioretinal inflammation in the foci, producing destruction of Bruch's membrane, the retinal pigment epithelium (RPE), and the outer retina. The focal scars showed migration of RPE and glial cells and neovascularisation. Capillary and venule endothelial cells were swollen at the inflammatory sites. Attempts to establish a cause for this condition were unsuccessful.
对一名患有多灶性后葡萄膜炎9年的59岁女性的尸检眼进行了病理研究。该疾病通过类固醇治疗得到控制，视觉功能得到良好保留。广泛的调查未发现病因。肉眼检查发现眼底散在许多不同程度色素沉着的局灶性病变。通过光镜、电镜和免疫组化对这些病变进行了研究。病灶处存在脉络膜视网膜炎症，导致布鲁赫膜、视网膜色素上皮（RPE）和视网膜外层遭到破坏。局灶性瘢痕显示RPE和神经胶质细胞迁移以及新生血管形成。炎症部位的毛细血管和小静脉内皮细胞肿胀。试图确定这种情况的病因但未成功。
