Yao Yilin
Department of Medical Oncology, Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China.
Zhongguo Fei Ai Za Zhi. 2012 Jan;15(1):27-33. doi: 10.3779/j.issn.1009-3419.2012.01.06.
Primary lung cancer is one of the most common malignant tumors. It causes great pain and mood disorders to patients, and significantly reduces their quality of life. The aim of the current study is to evaluate the effect of Feiji Decoction for soothing the liver combined with psychotherapy on quality of life (QoL) and physical status of patients with primary lung cancer.
A total of 118 patients with primary non-small cell lung cancer were randomly divided into two groups. The 57 patients in the combined therapy group were treated with Feiji Decoction for soothing the liver and psychotherapy combined with chemotherapy, whereas the 61 patients in the control group were treated with chemotherapy only. Both groups were observed for the two treatment courses. The European Organization for Research and Treatment of Cancer QoL Questionnaire LC-43 (EORTC QLQ-LC43) was used to assess the QoL of every patient in both groups before and after treatment scales. At the same time, physical status was assessed using the Karnofsky performance status (KPS) and East Cooperative Oncology Group performance status (ECOG).
The scores of physiology function, role function, emotion function, cognize function, society function, and general health in the therapy group were higher than that of the control group. The therapy group also showed better QoL results than the contol group. Significant differences were observed between the two groups (P<0.01). Meanwhile, the scores of fatigue, vomit, pain, polypnea, insomnia, anorexia, constipation, and specific manifestation of lung cancer in the therapy group were obviously lower than that of the control group; more patients were observed to be relieved. Significant differences between the two groups were observed (P<0.01). The KPS and ECOG scores of the patients were observed to have improved and stabilized in the therapy group than that of the control group; the differences were statistically significant (P<0.01).
Feiji Decoction for soothing the liver combined with psychotherapy can alleviate the clinical symptoms, elevate the physical status, and improve the QOL of patients with primary lung cancer. Thus, this therapy has a good clinical therapeutic effect.
原发性肺癌是最常见的恶性肿瘤之一。它给患者带来巨大痛苦和情绪障碍，并显著降低其生活质量。本研究旨在评估疏肝肺积方联合心理治疗对原发性肺癌患者生活质量（QoL）和身体状况的影响。
将118例原发性非小细胞肺癌患者随机分为两组。联合治疗组的57例患者采用疏肝肺积方、心理治疗联合化疗，而对照组的61例患者仅接受化疗。两组均观察两个疗程。使用欧洲癌症研究与治疗组织生活质量问卷LC - 43（EORTC QLQ - LC43）评估两组每位患者治疗前后的生活质量量表。同时，使用卡氏功能状态评分（KPS）和东部肿瘤协作组功能状态评分（ECOG）评估身体状况。
治疗组的生理功能、角色功能、情绪功能、认知功能、社会功能和总体健康评分均高于对照组。治疗组的生活质量结果也优于对照组。两组间差异有统计学意义（P<0.01）。同时，治疗组的疲劳、呕吐、疼痛、气促、失眠、厌食、便秘及肺癌特异性表现评分明显低于对照组；观察到更多患者症状缓解。两组间差异有统计学意义（P<0.01）。观察到治疗组患者的KPS和ECOG评分较对照组有所改善且稳定；差异有统计学意义（P<0.01）。
疏肝肺积方联合心理治疗可缓解原发性肺癌患者的临床症状，提高身体状况，改善生活质量。因此，该疗法具有良好的临床治疗效果。
