Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin Lung Cancer Center, Department of Thoracic Surgery, Tianjin, PR China.
Tianjin Medical University, Tianjin, PR China.
Lung Cancer. 2014 Jul;85(1):94-8. doi: 10.1016/j.lungcan.2014.04.006. Epub 2014 Apr 20.
To test the validity, reliability and acceptability of the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire-Lung Cancer 43 (EORTC QLQ-LC43) for Chinese patients with lung cancer.
Patients from Tianjin Cancer Institution and Hospital with lung cancer were enrolled in this study. All were treated in Tianjin Cancer Institution and Hospital from December 2012 to April 2013. All participants self-administered the EORTC QLQ-LC43 and the Short Form 36 Health Survey (SF-36). The Karnofsky performance scale (KPS) was performed to evaluate scores. Reliability test of the questionnaires was based on Cronbach's α coefficients, Pearson correlation test and Kruskal-Wallis test.
This study included 317 inpatients and outpatients. The Cronbach's α coefficients were >0.70 in all scales of the two questionnaires, except that of cognitive functioning. High correlations were found among the quality of life (QoL), physical functioning, role functioning, dyspnea, and KPS scores (r>0.40). Mild correlations were discovered among the rest of the items. Dividing the participants into three groups based on the KPS scores showed that QoL and functional scales scores progressively decreased and the symptom items scores progressively increased as KPS scores decreased. All inter-group differences were statistically significant (P<0.05).
The EORTC QLQ-LC43 is a reliable and valid instrument in patients with lung cancer and is appropriate for measuring the QoL of Chinese patients.
测试欧洲癌症研究与治疗组织肺癌生命质量问卷-43 版（EORTC QLQ-LC43）在中国肺癌患者中的有效性、信度和可接受性。
本研究纳入了来自天津肿瘤医院的肺癌患者。所有患者均于 2012 年 12 月至 2013 年 4 月在天津肿瘤医院接受治疗。所有参与者均自行填写 EORTC QLQ-LC43 和简明健康状况调查问卷 36 版（SF-36）。卡氏行为状态量表（KPS）用于评估得分。问卷的信度测试基于 Cronbach's α 系数、Pearson 相关检验和 Kruskal-Wallis 检验。
本研究共纳入 317 名住院和门诊患者。两个问卷的所有量表的 Cronbach's α 系数均>0.70，除认知功能量表外。生活质量（QoL）、身体功能、角色功能、呼吸困难和 KPS 评分之间存在高度相关性（r>0.40）。其余项目之间存在轻度相关性。根据 KPS 评分将参与者分为三组，结果显示 QoL 和功能量表评分随 KPS 评分的降低而逐渐降低，症状项目评分随 KPS 评分的降低而逐渐升高。所有组间差异均具有统计学意义（P<0.05）。
EORTC QLQ-LC43 是一种可靠且有效的肺癌患者生命质量测量工具，适用于测量中国肺癌患者的生命质量。
