Swiss Toxicological Information Centre, Associated Institute of the University of Zurich, Zurich, Switzerland.
Ann Emerg Med. 2012 Jul;60(1):97-9. doi: 10.1016/j.annemergmed.2011.11.018. Epub 2012 Jan 10.
Methoxetamine, the N-ethyl derivative of ketamine, is a novel recreational drug that is not at present subject to restrictive regulations in most countries. To our knowledge, no case of methoxetamine abuse has been published to date in the scientific literature, and the only sources of information are illegal drug users' Web discussion forums. We report the first case of analytically confirmed intravenous methoxetamine abuse in a 19-year-old man. Observed signs and symptoms such as tachycardia, hypertension, confusion, agitation, stupor, ataxia, mydriasis, and nystagmus were consistent with ketamine-induced adverse effects and resolved with symptomatic treatment. According to this case report, user Web reports, and the chemical structure, methoxetamine produces ketamine-like effects. Complete recovery can be expected with supportive care.
甲氧基埃他命，即氯胺酮的 N-乙基衍生物，是一种新型娱乐性药物，目前在大多数国家不受限制法规的约束。据我们所知，迄今为止，科学文献中尚未发表过甲氧基埃他命滥用的病例，唯一的信息来源是非法吸毒者的网络讨论论坛。我们报告了首例经分析证实的 19 岁男子静脉内滥用甲氧基埃他命的病例。观察到的体征和症状，如心动过速、高血压、意识混乱、激动、昏迷、共济失调、瞳孔散大、眼球震颤，与氯胺酮引起的不良反应一致，并通过对症治疗得到缓解。根据该病例报告、用户网络报告以及化学结构，甲氧基埃他命产生类似氯胺酮的作用。支持性治疗可预期完全恢复。
