Khatami Mohammad Reza, Mirchi Elham, Khazaeipour Zahra, Abdollahi Alireza, Jahanmardi Afsaneh
Nephrology Research Center, Tehran University of Medical Sciences, Tehran, Iran.
Iran J Kidney Dis. 2013 Jan;7(1):47-52.
There are associations between serum magnesium level and some risk factors of cardiovascular disease and atherosclerosis, such as lipid profile, serum albumin, C-reactive protein, serum phosphorus, parathyroid hormone, and diabetes mellitus in hemodialysis patients. The aim of this study was to examine these associations.
This study was conducted on 103 patients with end-stage renal disease on maintenance hemodialysis. Laboratory assessment was performed before hemodialysis session in a 12-hour fasting state. Patients were divided into two groups according to their serum magnesium concentration < 2.6 mg/dL, n = 34 and >= 2.6 mg/dL, n = 69).
The mean age of the patients was 57.4 +/- 15.4 years. The mean serum magnesium was 2.80 +/- 0.55 mg/dL (range, 1.7 mg/dL to 7 mg/dL). There were no significant differences in serum magnesium between patients with low and high values of high-density lipoprotein cholesterol, triglycerides, low-density lipoprotein cholesterol, and blood pressure. Of the 103 patients, 1 (1%) had hypomagnesemia, 41 (39.8%) had magnesium levels within normal range, and 61 (59.2%) had hypermagnesemia. Serum magnesium significantly correlated with plasma phosphorus level (r = 0.35, P < .001) and albumin (r = 0.24, P = .01). There were no correlations between serum magnesium level and age, body mass index, systolic blood pressure before dialysis, serum calcium, lipid profile, and apoprotein(a).
In our cohort of hemodialysis patients, there were no correlations between serum magnesium levels and atherogenic lipids, serum calcium, or parathyroid hormone.
血清镁水平与心血管疾病和动脉粥样硬化的一些危险因素之间存在关联，如血液透析患者的血脂谱、血清白蛋白、C反应蛋白、血清磷、甲状旁腺激素和糖尿病。本研究的目的是检验这些关联。
本研究对103例维持性血液透析的终末期肾病患者进行。在透析前12小时禁食状态下进行实验室评估。根据血清镁浓度将患者分为两组，血清镁浓度<2.6mg/dL（n = 34）和≥2.6mg/dL（n = 69）。
患者的平均年龄为57.4±15.4岁。平均血清镁为2.80±0.55mg/dL（范围为1.7mg/dL至7mg/dL）。高密度脂蛋白胆固醇、甘油三酯、低密度脂蛋白胆固醇和血压高低值患者之间的血清镁无显著差异。103例患者中，1例（1%）有低镁血症，41例（39.8%）镁水平在正常范围内，61例（59.2%）有高镁血症。血清镁与血浆磷水平显著相关（r = 0.35，P <.001）和白蛋白（r = 0.24，P =.01）。血清镁水平与年龄、体重指数、透析前收缩压、血清钙、血脂谱和载脂蛋白(a)之间无相关性。
在我们的血液透析患者队列中，血清镁水平与致动脉粥样硬化脂质、血清钙或甲状旁腺激素之间无相关性。
