Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, SC, USA.
Neurochem Res. 2012 Jun;37(6):1137-49. doi: 10.1007/s11064-011-0692-y. Epub 2012 Jan 12.
The neutral sphingomyelinases (N-SMases) are a group of Mg²⁺-dependent enzymes with a pH optimum in the neutral range. N-SMases catalyze the conversion of sphingomyelin to ceramide and have been found particularly enriched in brain tissue. N-SMase activity has been implicated in many physiological and pathological processes affecting the brain and nervous system. In this review, we discuss the proposed functions of N-SMase with a particular emphasis on its role in neurological disorders, such as age-related neurodegeneration, Alzheimer's disease, HIV-associated dementia, atherosclerosis, ischemia-reperfusion injury, and cancer.
中性鞘磷脂酶（N-SMases）是一组依赖于镁离子的酶，最适 pH 值在中性范围内。N-SMases 催化鞘磷脂转化为神经酰胺，在脑组织中特别丰富。N-SMase 活性与影响大脑和神经系统的许多生理和病理过程有关。在这篇综述中，我们讨论了 N-SMase 的拟议功能，特别强调了它在神经退行性疾病中的作用，如与年龄相关的神经退行性变、阿尔茨海默病、HIV 相关痴呆、动脉粥样硬化、缺血再灌注损伤和癌症。
