Khelemsky Yury, Noto Christopher J
Department of Anesthesiology, Mount Sinai School of Medicine, New York, NY, USA.
Mt Sinai J Med. 2012 Jan-Feb;79(1):133-9. doi: 10.1002/msj.21286.
This article provides a concise overview of post-thoracotomy pain syndrome, describes anesthetic and surgical factors that have been investigated to reduce the incidence of the syndrome, and explores the effectiveness of various treatments for this condition. Although some interventions (both procedural and pharmacologic) have been investigated in both preventing and treating post-thoracotomy pain syndrome, definitive studies are lacking and firm conclusions regarding the benefit of any intervention cannot be drawn. The problem is compounded further by our lack of understanding of the pathophysiologic mechanisms underlying the development of chronic pain after surgery. Going forward, it will be important to elucidate these mechanisms and conduct well-designed trials involving novel therapeutic agents for both prevention and treatment of post-thoracotomy pain syndrome.
本文简要概述了开胸术后疼痛综合征，描述了为降低该综合征发生率而研究的麻醉和手术因素，并探讨了针对这种情况的各种治疗方法的有效性。尽管已经对一些干预措施（包括手术和药物方面）在预防和治疗开胸术后疼痛综合征方面进行了研究，但仍缺乏确定性研究，无法就任何干预措施的益处得出确凿结论。我们对手术后慢性疼痛发生的病理生理机制缺乏了解，这使问题更加复杂。展望未来，阐明这些机制并开展涉及新型治疗药物的精心设计的试验，对于预防和治疗开胸术后疼痛综合征将非常重要。
