Mizuseki Kenji, Buzsaki György
NYU Neuroscience Institute, Langone Medical Center, New York University, , New York, NY 10016, USA.
Philos Trans R Soc Lond B Biol Sci. 2013 Dec 23;369(1635):20120530. doi: 10.1098/rstb.2012.0530. Print 2014 Feb 5.
Oscillations and synchrony are often used synonymously. However, oscillatory mechanisms involving both excitation and inhibition can generate non-synchronous yet coordinated firing patterns. Using simultaneous recordings from multiple layers of the entorhinal-hippocampal loop, we found that coactivation of principal cell pairs (synchrony) was lowest during exploration and rapid-eye-movement (REM) sleep, associated with theta oscillations, and highest in slow wave sleep. Individual principal neurons had a wide range of theta phase preference. Thus, while theta oscillations reduce population synchrony, they nevertheless coordinate the phase (temporal) distribution of neurons. As a result, multiple cell assemblies can nest within the period of the theta cycle.
振荡和同步通常被视为同义词。然而，涉及兴奋和抑制的振荡机制可以产生非同步但协调的放电模式。通过对内嗅-海马环路多层进行同步记录，我们发现主细胞对的共同激活（同步）在探索和快速眼动（REM）睡眠期间最低，与θ振荡相关，而在慢波睡眠中最高。单个主神经元具有广泛的θ相位偏好。因此，虽然θ振荡会降低群体同步性，但它们仍然可以协调神经元的相位（时间）分布。结果，多个细胞集合可以嵌套在θ周期内。
