Unitat de Biologia Cel·lular, Facultat de Biociències, Universitat Autònoma de Barcelon , Bellaterra (Cerdanyola del Vallès), Spain.
Syst Biol Reprod Med. 2012 Feb;58(1):41-50. doi: 10.3109/19396368.2011.637152.
Establishing specific biomarkers for the assessment of human male fertility status is an important goal to ensure the fitness of the male contribution so as to support the birth of a healthy child. Spermatozoa are considered an optimal surrogate tissue for the evaluation of spermatogenic function. Unlike the cells of the testis, spermatozoa do not require invasive procedures to procure a sample. A broad range of sperm biomarkers and tests have been described as useful for the assessment of the sperm function. However, these approaches appear limited considering the current state of the art of molecular diagnostics that could be developed for this purpose. In this review, we outline the suite of sperm biomarkers that are currently in use to assess human male fertility status. Their use as indicators of genotoxic exposure will be discussed.
建立用于评估人类男性生育能力的特定生物标志物是一个重要目标，这有助于确保男性生育力的健康，从而支持健康孩子的诞生。精子被认为是评估精子发生功能的最佳替代组织。与睾丸细胞不同，精子不需要进行侵入性程序即可获得样本。已经描述了广泛的精子生物标志物和测试方法，这些方法可用于评估精子功能。然而，考虑到为此目的可能开发的分子诊断学的当前最新技术水平，这些方法似乎受到限制。在这篇综述中，我们概述了目前用于评估人类男性生育能力的一系列精子生物标志物。我们将讨论它们作为遗传毒性暴露的指标的用途。
