Frontera Walter R, Zayas Ana Rodriguez, Rodriguez Natividad
Department of Physical Medicine and Rehabilitation, University of Puerto Rico School of Medicine, San Juan, PR 00936, USA.
Phys Med Rehabil Clin N Am. 2012 Feb;23(1):201-7, xiii. doi: 10.1016/j.pmr.2011.11.012. Epub 2011 Dec 13.
The loss of muscle mass with age, also known as sarcopenia, is a major scientific and public health problem. Muscle atrophy is associated with the loss of functional capacity and poor health outcomes in elderly men and women. A detailed understanding of this problem in humans can be enhanced by the use of experiments with single muscle fibers. It is likely that both muscle atrophy and a decrease in muscle-fiber quality contribute to muscle dysfunction among the elderly. A better understanding of sarcopenia at the single-fiber level may lead to the design of more effective rehabilitative interventions.
随着年龄增长出现的肌肉量减少，即肌肉减少症，是一个重大的科学和公共卫生问题。肌肉萎缩与老年男性和女性的功能能力丧失及健康状况不佳有关。通过对单根肌纤维进行实验，能够更深入地了解人类的这一问题。肌肉萎缩和肌纤维质量下降可能都导致了老年人的肌肉功能障碍。在单纤维水平上更好地理解肌肉减少症，可能会促成更有效的康复干预措施的设计。
