Cancer Biology Program, University of Hawaii Cancer Center, University of Hawaii at Manoa, Honolulu, HI 96813, USA.
Arch Biochem Biophys. 2012 Aug 1;524(1):16-22. doi: 10.1016/j.abb.2011.12.027. Epub 2012 Jan 3.
Gap junction channels provide a conduit for communication between neighboring cells. The function of gap junction channels is regulated by posttranslational modifications of connexins, the proteins that comprise these channels. Ubiquitination of connexins has increasingly been viewed as one mechanism by which cells regulate the level of connexins present in cells, as well as the corresponding intercellular communication. Here we review the current knowledge of connexin ubiquitination and the effects this may have on gap junctional communication.
缝隙连接通道为相邻细胞之间的通讯提供了一个通道。缝隙连接通道的功能受连接蛋白的翻译后修饰调节，这些通道由连接蛋白组成。连接蛋白的泛素化越来越被视为细胞调节细胞中存在的连接蛋白水平以及相应的细胞间通讯的一种机制。在这里，我们回顾了连接蛋白泛素化的最新知识及其对缝隙连接通讯可能产生的影响。
