线粒体 K(ATP) 通道——事实还是虚构？
The mitochondrial K(ATP) channel--fact or fiction?
机构信息
Department of Biology, Portland State University, Portland, OR 97201-0751, USA.
出版信息
J Mol Cell Cardiol. 2012 Mar;52(3):578-83. doi: 10.1016/j.yjmcc.2011.12.011. Epub 2012 Jan 2.
Abstract
The mitochondrial ATP-dependent K(+) channel (mitoK(ATP)) is widely considered by many to play a central role in cardioprotection by ischemic and pharmacological preconditioning and by ischemic postconditioning. Nevertheless, several laboratories have questioned the existence of mitoK(ATP). This article summarizes the evidence for and against and addresses two key questions: How strong is the evidence for the presence of a K(ATP) channel in mitochondria? Are the pharmacological agents used to modulate mitoK(ATP) activity sufficiently specific to allow the role of these channels in cardioprotection to be established?
摘要
线粒体三磷酸腺苷依赖性钾（mitoKATP）通道被许多人广泛认为在缺血和药物预处理以及缺血后处理的心脏保护中发挥核心作用。然而，一些实验室对 mitoKATP 的存在提出了质疑。本文总结了支持和反对的证据，并回答了两个关键问题：证明线粒体中存在 KATP 通道的证据有多强？用于调节 mitoKATP 活性的药物在多大程度上足够特异，以确定这些通道在心脏保护中的作用？
相似文献
1
The mitochondrial K(ATP) channel--fact or fiction?线粒体 K(ATP) 通道——事实还是虚构？
J Mol Cell Cardiol. 2012 Mar;52(3):578-83. doi: 10.1016/j.yjmcc.2011.12.011. Epub 2012 Jan 2.
2
Essential role of mitochondrial Ca2+-activated and ATP-sensitive K+ channels in sildenafil-induced late cardioprotection.线粒体钙激活及ATP敏感性钾通道在西地那非诱导的延迟性心脏保护中的重要作用
J Mol Cell Cardiol. 2008 Jan;44(1):105-13. doi: 10.1016/j.yjmcc.2007.10.006. Epub 2007 Oct 16.
3
MCC-134, a single pharmacophore, opens surface ATP-sensitive potassium channels, blocks mitochondrial ATP-sensitive potassium channels, and suppresses preconditioning.MCC - 134，一种单一药效基团，可打开细胞膜上的ATP敏感性钾通道，阻断线粒体ATP敏感性钾通道，并抑制预处理。
Circulation. 2003 Mar 4;107(8):1183-8. doi: 10.1161/01.cir.0000051457.64240.63.
4
Selective pharmacological agents implicate mitochondrial but not sarcolemmal K(ATP) channels in ischemic cardioprotection.选择性药理制剂表明，线粒体而非肌膜的ATP敏感性钾通道参与缺血性心脏保护作用。
Circulation. 2000 May 23;101(20):2418-23. doi: 10.1161/01.cir.101.20.2418.
5
Mitochondrial K(ATP) channel as an end effector of cardioprotection during late preconditioning: triggering role of nitric oxide.线粒体ATP敏感性钾通道作为晚期预处理心脏保护的终效应器：一氧化氮的触发作用
J Mol Cell Cardiol. 2001 Nov;33(11):2037-46. doi: 10.1006/jmcc.2001.1468.
6
P1075 opens mitochondrial K(ATP) channels and generates reactive oxygen species resulting in cardioprotection of rabbit hearts.P1075可打开线粒体ATP敏感性钾通道并产生活性氧，从而对兔心脏起到心脏保护作用。
J Mol Cell Cardiol. 2003 Sep;35(9):1035-42. doi: 10.1016/s0022-2828(03)00151-2.
7
Activation of mitochondrial ATP-sensitive K(+) channel for cardiac protection against ischemic injury is dependent on protein kinase C activity.线粒体ATP敏感性钾通道激活对心脏缺血性损伤的保护作用依赖于蛋白激酶C活性。
Circ Res. 1999 Oct 15;85(8):731-41. doi: 10.1161/01.res.85.8.731.
8
The Slo(w) path to identifying the mitochondrial channels responsible for ischemic protection.识别负责缺血保护的线粒体通道的缓慢之路。
Biochem J. 2017 Jun 9;474(12):2067-2094. doi: 10.1042/BCJ20160623.
9
Volatile anesthetics mimic cardiac preconditioning by priming the activation of mitochondrial K(ATP) channels via multiple signaling pathways.挥发性麻醉剂通过多种信号通路启动线粒体ATP敏感性钾通道的激活，从而模拟心脏预处理。
Anesthesiology. 2002 Jul;97(1):4-14. doi: 10.1097/00000542-200207000-00003.
10
Mitochondrial ROMK channel is a molecular component of mitoK(ATP).线粒体 ROMK 通道是 mitoK(ATP)的分子组成部分。
Circ Res. 2012 Aug 3;111(4):446-54. doi: 10.1161/CIRCRESAHA.112.266445. Epub 2012 Jul 17.
引用本文的文献
1
Redox Regulation of Mitochondrial Potassium Channels Activity.线粒体钾通道活性的氧化还原调节
Antioxidants (Basel). 2024 Apr 3;13(4):434. doi: 10.3390/antiox13040434.
2
Mitochondrial Cation Signalling in the Control of Inflammatory Processes.线粒体阳离子信号在炎症过程调控中的作用。
Int J Mol Sci. 2023 Nov 24;24(23):16724. doi: 10.3390/ijms242316724.
3
Ischemic Tolerance-A Way to Reduce the Extent of Ischemia-Reperfusion Damage.缺血耐受——减少缺血再灌注损伤程度的一种方法。
Cells. 2023 Mar 13;12(6):884. doi: 10.3390/cells12060884.
4
Cardioprotective mechanisms of mitochondria-targeted S-nitrosating agent and adenosine triphosphate-sensitive potassium channel opener are mutually exclusive.线粒体靶向性S-亚硝基化剂与三磷酸腺苷敏感性钾通道开放剂的心脏保护机制相互排斥。
JTCVS Open. 2021 Aug 8;8:338-354. doi: 10.1016/j.xjon.2021.07.036. eCollection 2021 Dec.
5
Kir6.1 and SUR2B in Cantú syndrome.Cantú 综合征中的 Kir6.1 和 SUR2B。
Am J Physiol Cell Physiol. 2022 Sep 1;323(3):C920-C935. doi: 10.1152/ajpcell.00154.2022. Epub 2022 Jul 25.
6
Molecular Signaling to Preserve Mitochondrial Integrity against Ischemic Stress in the Heart: Rescue or Remove Mitochondria in Danger.分子信号在心脏对抗缺血应激中保护线粒体完整性：拯救或清除危险的线粒体。
Cells. 2021 Nov 27;10(12):3330. doi: 10.3390/cells10123330.
7
Mitochondrial H Leak and Thermogenesis.线粒体 H 渗漏与产热。
Annu Rev Physiol. 2022 Feb 10;84:381-407. doi: 10.1146/annurev-physiol-021119-034405. Epub 2021 Nov 10.
8
Mitochondrial ion channels in cardiac function.线粒体离子通道与心脏功能。
Am J Physiol Cell Physiol. 2021 Nov 1;321(5):C812-C825. doi: 10.1152/ajpcell.00246.2021. Epub 2021 Sep 22.
9
Mitochondrial Potassium Channels as Druggable Targets.线粒体钾通道作为可药物作用的靶点。
Biomolecules. 2020 Aug 18;10(8):1200. doi: 10.3390/biom10081200.
10
Repurposing Kir6/SUR2 Channel Activator Minoxidil to Arrests Growth of Gynecologic Cancers.将钾离子通道Kir6/SUR2激活剂米诺地尔重新用于抑制妇科癌症生长。
Front Pharmacol. 2020 May 8;11:577. doi: 10.3389/fphar.2020.00577. eCollection 2020.
本文引用的文献
1
Mitochondrial approaches to protect against cardiac ischemia and reperfusion injury.用于预防心脏缺血再灌注损伤的线粒体方法。
Front Physiol. 2011 Apr 12;2:13. doi: 10.3389/fphys.2011.00013. eCollection 2011.
2
The mitochondrial complex II and ATP-sensitive potassium channel interaction: quantitation of the channel in heart mitochondria.线粒体复合物II与ATP敏感性钾通道的相互作用：心脏线粒体中该通道的定量分析
Acta Biochim Pol. 2010;57(4):431-4. Epub 2010 Nov 19.
3
Mechanism of cardioprotection by early ischemic preconditioning.早期缺血预处理的心脏保护机制。
Cardiovasc Drugs Ther. 2010 Jun;24(3):225-34. doi: 10.1007/s10557-010-6236-x.
4
A novel mitochondrial K(ATP) channel assay.一种新型的线粒体 K(ATP) 通道检测方法。
Circ Res. 2010 Apr 16;106(7):1190-6. doi: 10.1161/CIRCRESAHA.109.215400. Epub 2010 Feb 25.
5
Potential therapeutic benefits of strategies directed to mitochondria.靶向线粒体的治疗策略的潜在治疗益处。
Antioxid Redox Signal. 2010 Aug 1;13(3):279-347. doi: 10.1089/ars.2009.2788.
6
Ambivalent effects of diazoxide on mitochondrial ROS production at respiratory chain complexes I and III.二氮嗪对呼吸链复合体I和III处线粒体活性氧生成的矛盾作用。
Biochim Biophys Acta. 2009 Jun;1790(6):558-65. doi: 10.1016/j.bbagen.2009.01.011. Epub 2009 Feb 6.
7
The complex II inhibitor atpenin A5 protects against cardiac ischemia-reperfusion injury via activation of mitochondrial KATP channels.复合物II抑制剂Atpenin A5通过激活线粒体ATP敏感性钾通道来保护心脏免受缺血再灌注损伤。
Basic Res Cardiol. 2009 Mar;104(2):121-9. doi: 10.1007/s00395-009-0001-y. Epub 2009 Feb 26.
8
Cardioprotective signaling to mitochondria.对线粒体的心脏保护信号传导
J Mol Cell Cardiol. 2009 Jun;46(6):858-66. doi: 10.1016/j.yjmcc.2008.11.019. Epub 2008 Dec 11.
9
Determination of the rate of K(+) movement through potassium channels in isolated rat heart and liver mitochondria.测定钾离子通过分离的大鼠心脏和肝脏线粒体中钾通道的移动速率。
Biochim Biophys Acta. 2008 Jun;1777(6):540-8. doi: 10.1016/j.bbabio.2008.04.018. Epub 2008 Apr 18.
10
The endogenous mitochondrial complex II inhibitor malonate regulates mitochondrial ATP-sensitive potassium channels: implications for ischemic preconditioning.内源性线粒体复合物II抑制剂丙二酸酯调节线粒体ATP敏感性钾通道：对缺血预处理的影响。
Biochim Biophys Acta. 2008 Jul-Aug;1777(7-8):882-9. doi: 10.1016/j.bbabio.2008.03.025. Epub 2008 Apr 8.
Zotero 插件