University of Lisbon Medical School, Santa Maria Hospital, Lisbon, Portugal.
Clin Hemorheol Microcirc. 2012;51(1):1-20. doi: 10.3233/CH-2011-1512.
The erythrocytes ability of sensing the local oxygen gradient through the hemoglobin conformation, along with changes in nitric oxide mobilization and vasomotor repercussions at the microcirculation, were reviewed in detail in this article. Different approachs trying to explain the erythrocyte death were additionally documented. Also, the influence of several types of molecules (vasoactive, oxidant/reductor) on the erythrocyte roles as sensor of (i) oxygen tissue needs, (ii) blood viscosity and myogenic environment, (iii) and inflammatory conditions were mentioned in order to highlight its physiologycal function and substitute the erroneous idea of the erythrocyte being simply a hemoglobin sac content.
本文详细回顾了通过血红蛋白构象感知局部氧梯度的红细胞能力，以及一氧化氮动员和微循环血管舒缩反应的变化。此外，还记录了几种试图解释红细胞死亡的不同方法。还提到了几种类型的分子（血管活性、氧化还原）对红细胞作为（i）组织氧气需求、（ii）血液粘度和肌源性环境、（iii）炎症条件传感器的作用的影响，以突出其生理功能，并替代红细胞仅仅是血红蛋白囊内容物的错误观念。
