Department of Biochemistry and Molecular Biology, Baotou Medical College, Baotou, 014040 Inner Mongolia, China.
Department of Endocrinology, Affiliated Hospital of Inner Mongolia Medical University, Hohhot, 010050 Inner Mongolia, China.
J Diabetes Res. 2021 Feb 25;2021:6656062. doi: 10.1155/2021/6656062. eCollection 2021.
High blood glucose level (hyperglycemia) is a leading indicator of diabetes mellitus (DM). Erythrocytes are the most abundant cells in the circulation and the first to perceive changes in plasma composition. Long-lasting hyperglycemia affects the structure and function of erythrocytes. The detection of erythrocyte-related indicators can provide a valuable reference for the prevention, diagnosis, and treatment of DM and its complications. This paper reviews the normal structure and function of erythrocytes, the changes in erythrocytes in patients with diabetes, and the role of erythrocytes in the development of diabetic complications to provide more indicators for the early prevention of DM complications and to monitor the therapeutic effect of DM.
高血糖水平（高血糖症）是糖尿病（DM）的主要指标。红细胞是循环中最丰富的细胞，也是最先感知血浆成分变化的细胞。长期的高血糖会影响红细胞的结构和功能。红细胞相关指标的检测可为 DM 及其并发症的预防、诊断和治疗提供有价值的参考。本文综述了红细胞的正常结构和功能、糖尿病患者红细胞的变化以及红细胞在糖尿病并发症发展中的作用，为 DM 并发症的早期预防提供更多指标，并监测 DM 的治疗效果。
