Shulman A G
Department of Surgery, Cedars-Sinai Medical Center, Los Angeles, CA 90048.
Biomed Pharmacother. 1990;44(6):303-6. doi: 10.1016/0753-3322(90)90133-t.
Both animal and clinical evidence of the special role of long-term low-dose heparin as a preventative of atherosclerosis is presented. Some of the many beneficial effects of heparin aside from its anticoagulant capability are mentioned. Concern about hemorrhage and osteoporosis which can occur when taken in the usual anticoagulant doses does not apply to long-term administration of low-dose heparin. Taken by the intrapulmonary route using an ultrasonic nebulizer weekly or fortnightly, heparin is safe and assures patient compliance. Further clinical trials are strongly indicated.
本文提供了动物和临床证据，证明长期小剂量肝素在预防动脉粥样硬化方面具有特殊作用。文中提到了肝素除抗凝能力外的许多有益作用。通常抗凝剂量使用时可能出现的出血和骨质疏松问题，不适用于长期小剂量肝素给药。通过超声雾化器每周或每两周经肺内途径给药，肝素是安全的，并能确保患者的依从性。强烈建议进行进一步的临床试验。
