Biozentrum, University of Basel, Klingelbergstrasse 50/70, 4056 Basel, Switzerland.
EMBO Rep. 2012 Feb 1;13(2):121-8. doi: 10.1038/embor.2011.257.
TOR is a conserved serine/threonine kinase that responds to nutrients, growth factors, the bioenergetic status of the cell and cellular stress to control growth, metabolism and ageing. A diverse group of small GTPases including Rheb, Rag, Rac1, RalA and Ryh1 play a variety of roles in the regulation of TOR. For example, while Rheb binds to and activates TOR directly, Rag and Rac1 regulate its localization and RalA activates it indirectly through the production of phosphatidic acid. Here, we review recent findings on the regulation of TOR by small GTPases.
TOR 是一种保守的丝氨酸/苏氨酸激酶，它响应营养物质、生长因子、细胞的生物能量状态和细胞应激，以控制生长、代谢和衰老。包括 Rheb、Rag、Rac1、RalA 和 Ryh1 在内的多种小 GTPases 在 TOR 的调节中发挥着多种作用。例如，虽然 Rheb 直接结合并激活 TOR，但 Rag 和 Rac1 调节其定位，而 RalA 通过产生磷脂酸间接激活它。在这里，我们回顾了小 GTPases 对 TOR 调节的最新发现。
