mTOR 信号通路与疾病。
mTOR signaling in disease.
机构信息
Biozentrum, University of Basel, CH4056 Basel, Switzerland.
出版信息
Curr Opin Cell Biol. 2011 Dec;23(6):744-55. doi: 10.1016/j.ceb.2011.09.003. Epub 2011 Sep 29.
PMID:21963299
Abstract
The target of rapamycin (TOR) is a highly conserved serine/threonine kinase and a central controller of cell growth, metabolism and aging. Mammalian TOR (mTOR) is activated in response to nutrients, growth factors and cellular energy. Dysregulated mTOR signaling has been implicated in major disease. Here we review recent findings on the role of mTOR in cancer, metabolic disorders, neurological diseases, and inflammation.
摘要
雷帕霉素靶蛋白（TOR）是一种高度保守的丝氨酸/苏氨酸激酶，也是细胞生长、代谢和衰老的中央控制器。哺乳动物雷帕霉素靶蛋白（mTOR）在响应营养物质、生长因子和细胞能量时被激活。mTOR 信号的失调与多种疾病有关。本文综述了 mTOR 在癌症、代谢紊乱、神经退行性疾病和炎症中的作用的最新发现。
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