Shiraki Ayako, Hojo Yuri, Tsuchiya Takuma, Wang Liyun, Ohishi Takumi, Suzuki Kazuhiko, Mitsumori Kunitoshi, Shibutani Makoto
Laboratory of Veterinary Pathology, Tokyo University of Agriculture and Technology, 3-5-8 Saiwai-cho, Fuchu, Tokyo 183-8509, Japan.
J Vet Med Sci. 2012 Jun;74(6):801-4. doi: 10.1292/jvms.11-0532. Epub 2012 Jan 12.
A rare case of complex apocrine carcinoma displaying dominant myoepithelial proliferation developed in the right leg subcutis of a 10-year-old male dog. The major cell population consisted of diffusely proliferating p63-expressing neoplastic cells that were largely myoepithelial in origin co-expressing α-smooth muscle actin. A small portion of the cell population consisted of concomitant basal epithelial cells lacking α-smooth muscle actin expression. The minor population consisted of p63-negative apocrine gland cells that expressed cytokeratin 8. The myoepithelial cell population showed a rather stronger proliferation activity than did the apocrine epithelial population. Thus, this tumor might have been derived from basal epithelial cells characterized by more predominant myoepithelial differentiation than luminal apocrine epithelial differentiation.
一只10岁雄性犬的右下肢皮下发生了一例罕见的伴有显著肌上皮细胞增生的复杂性大汗腺癌。主要细胞群由弥漫性增生的表达p63的肿瘤细胞组成，这些细胞主要起源于肌上皮细胞，同时表达α-平滑肌肌动蛋白。一小部分细胞群由缺乏α-平滑肌肌动蛋白表达的伴行基底上皮细胞组成。次要细胞群由表达细胞角蛋白8的p63阴性大汗腺细胞组成。肌上皮细胞群的增殖活性比大汗腺上皮细胞群更强。因此，该肿瘤可能起源于基底上皮细胞，其特征是肌上皮分化比管腔大汗腺上皮分化更显著。
