Yoshimura H, Nakahira R, Kishimoto T E, Michishita M, Ohkusu-Tsukada K, Takahashi K
Department of Veterinary Pathology, Nippon Veterinary and Life Science University (NVLU), Tokyo, Japan.
Department of Veterinary Pathology, Nippon Veterinary and Life Science University (NVLU), Tokyo, Japan
Vet Pathol. 2014 Nov;51(6):1090-5. doi: 10.1177/0300985813516637. Epub 2014 Jan 21.
Routinely diagnosed simple solid carcinoma (SSC) of the canine mammary gland comprises a heterogeneous group of tumors. Seventy-two cases that had been diagnosed as SSC based on hematoxylin and eosin-stained tissue sections were reclassified immunohistochemically on the basis of myoepithelial markers p63 and α-smooth muscle actin, as well as a luminal epithelial marker cytokeratin 8. Only 23 cases (32%) were true SSC, composed only of luminal epithelial cells, whereas 11 cases (15%) were malignant myoepithelioma (MM), composed predominantly of myoepithelial cells, and 38 cases (53%) were biphasic carcinoma (BC), characterized by biphasic proliferation of luminal epithelial and basal/myoepithelial components. As the pathological parameters were compared between the reclassified tumor types, infiltrative potential, vascular/lymphatic invasion, lymph node metastasis, and Ki-67 labeling index were higher in true SSC compared with MM and BC, suggesting that the former may exhibit a poorer prognosis compared with the latter two.
犬乳腺常规诊断的单纯实性癌（SSC）是一组异质性肿瘤。根据苏木精和伊红染色的组织切片诊断为SSC的72例病例，基于肌上皮标志物p63和α平滑肌肌动蛋白以及管腔上皮标志物细胞角蛋白8进行免疫组化重新分类。仅23例（32%）为真正的SSC，仅由管腔上皮细胞组成，而11例（15%）为恶性肌上皮瘤（MM），主要由肌上皮细胞组成，38例（53%）为双相癌（BC），其特征为管腔上皮和基底/肌上皮成分的双相增殖。在重新分类的肿瘤类型之间比较病理参数时，真正的SSC与MM和BC相比，浸润潜能、血管/淋巴管侵犯、淋巴结转移和Ki-67标记指数更高，提示前者与后两者相比可能预后更差。
