Department of Radiation Oncology, University of Michigan, Ann Arbor, MI, USA.
Neoplasia. 2011 Dec;13(12):1183-93. doi: 10.1593/neo.111746.
The elegance of fundamental and applied research activities have begun to reveal a myriad of spatial and temporal alterations in downstream signaling networks affected by cell surface receptor stimulation including G protein-coupled receptors and receptor tyrosine kinases. Interconnected biochemical pathways serve to integrate and distribute the signaling information throughout the cell by orchestration of complex biochemical circuits consisting of protein interactions and covalent modification processes. It is clear that scientific literature summarizing results from both fundamental and applied scientific research activities has served to provide a broad foundational biologic database that has been instrumental in advancing our continued understanding of underlying cancer biology. This article reflects on historical advances and the role of innovation in the competitive world of grant-sponsored research.
基础研究和应用研究活动的精妙之处开始揭示出受细胞表面受体刺激影响的下游信号转导网络的无数时空改变，这些受体包括 G 蛋白偶联受体和受体酪氨酸激酶。相互关联的生化途径通过由蛋白质相互作用和共价修饰过程组成的复杂生化电路的协调，来整合和分布信号信息。显然，总结基础研究和应用科学研究活动结果的科学文献为推进我们对癌症生物学基础的持续理解提供了广泛的基础生物学数据库。本文反映了历史进展和创新在资助研究的竞争世界中的作用。
