Ito Shunichiro, Konishi Taisuke, Imazuru Tomohiro, Matsuzaki Kanji, Jikuya Tomoaki
Department of Cardiovascular Surgery, Tsukuba Medical Center Hospital, Tsukuba, Japan.
Kyobu Geka. 2011 Dec;64(13):1141-4.
Tachyarrhythmia, especially atrial fibrillation, remains as a common complication after open heart surgery and sometimes leads to fatal condition. Many reports showed that landiolol (ultra short-acting beta one blocker) and amiodarone were effective against postoperative atrial fibrillation (POAF). However, there were few comparative studies between these 2 drugs as prophylactic agents, and no report mentioned the therapeutic efficacy. Our study suggests that landiolol be the 1st choice for rate control of tachyarrhythmia because of easy dose adjustment and mild side effects. Amiodarone may be useful for the patients whose left ventricular function is poor.
快速心律失常,尤其是心房颤动,仍是心脏直视手术后常见的并发症,有时会导致致命状况。许多报告显示,兰地洛尔(超短效β1受体阻滞剂)和胺碘酮对术后心房颤动(POAF)有效。然而,这两种药物作为预防药物的比较研究很少,也没有报告提及治疗效果。我们的研究表明,由于剂量调整容易且副作用轻微,兰地洛尔是快速心律失常心率控制的首选药物。胺碘酮可能对左心室功能较差的患者有用。