R. Madhavan Nayar Center for Comprehensive Epilepsy Care, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Trivandrum, Kerala, India.
Epilepsia. 2012 Apr;53(4):e60-2. doi: 10.1111/j.1528-1167.2011.03386.x. Epub 2012 Jan 13.
In areas where cysticercosis is endemic, calcified neurocysticercosis lesion(s) (CNL) and hippocampal sclerosis (HS) commonly coexist in patients with localization-related epilepsies. To understand the pathogenesis of HS associated with CNL, we compared the characteristics of three groups of patients with antiepileptic drug-resistant epilepsies: CNL with HS, CNL without HS (CNL alone), and HS without CNL (HS alone). In comparison to patients with CNL alone, those with CNL with HS had CNL more frequently located in the ipsilateral temporal lobe. Those with CNL with HS had a lower incidence of febrile seizures, older age at initial precipitating injury and at onset of habitual complex partial seizures, and more frequent clustering of seizures and extratemporal/bitemporal interictal epileptiform discharges as compared to patients with HS alone. Our study illustrates that HS associated with CNL might have a different pathophysiologic basis as compared to classical HS.
在囊虫病流行地区，伴有定位相关癫痫的患者常同时存在脑囊尾蚴病钙化性病变（CNL）和海马硬化（HS）。为了了解与 CNL 相关的 HS 的发病机制，我们比较了三组抗癫痫药物耐药性癫痫患者的特征：伴有 HS 的 CNL、无 HS 的 CNL（单纯 CNL）和无 CNL 的 HS（单纯 HS）。与单纯 CNL 患者相比，伴有 HS 的 CNL 患者的 CNL 更常位于同侧颞叶。伴有 HS 的 CNL 患者的热性惊厥发生率较低，初次促发损伤和习惯性复杂部分性癫痫发作的年龄较大，癫痫发作和局灶性/双侧颞叶间发性癫痫样放电的聚集更为频繁。我们的研究表明，与经典 HS 相比，与 CNL 相关的 HS 可能具有不同的病理生理基础。
