Department of Dermatology, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Dermatol Surg. 2012 May;38(5):709-21. doi: 10.1111/j.1524-4725.2011.02271.x. Epub 2012 Jan 13.
Practitioners are increasingly using topical anesthetics to decrease the pain associated with superficial dermatologic, aesthetic, and laser procedures. Numerous lidocaine-containing products are available, but comprehensive reviews are lacking regarding their relative safety profiles and appropriate dermatologic uses.
A literature review of currently available topical anesthetics, their safety profiles, and dermatologic uses was conducted.
Factors that should be considered to reduce the risk of side effects associated with the use of topical anesthetics include the amount of product used, body location, size of the surface area, and duration of product application. Many case reports document adverse outcomes associated with the use of compounded products that the Food and Drug Administration has not approved that have inappropriately high anesthetic concentrations and from the use of topical anesthetics on excessively large skin surface areas during laser treatments.
Lidocaine-containing products play an integral role in cutaneous anesthesia by providing patient comfort with minimal side effects. Careful attention must be paid to the particular anatomic location, the total surface area covered, and the duration of anesthetic skin contact.
从业者越来越多地使用局部麻醉剂来减轻与浅表皮肤、美容和激光手术相关的疼痛。有许多含有利多卡因的产品,但缺乏关于它们相对安全概况和适当皮肤科用途的综合评价。
对现有的局部麻醉剂、其安全性概况和皮肤科用途进行了文献回顾。
为了降低与使用局部麻醉剂相关的副作用风险,应考虑以下因素:使用的产品量、身体部位、表面积大小和产品应用持续时间。许多病例报告记录了与使用未经食品和药物管理局批准的、麻醉浓度过高的复合产品以及在激光治疗时将局部麻醉剂应用于过大的皮肤表面积相关的不良后果。
含利多卡因的产品通过提供最小副作用的患者舒适度,在皮肤麻醉中发挥着重要作用。必须仔细注意特定的解剖位置、覆盖的总表面积和麻醉皮肤接触的持续时间。