Istituto San Gallicano, UOSD Prevenzione e Promozione della Salute in DermatologiaIFO, Rome, Italy -
G Ital Dermatol Venereol. 2013 Oct;148(5):465-9.
The aim of our study is to value the vasoconstrictor effect of two most utilized topical anesthetics, the first one containing a mixture 2.5% lidocaine and 2.5% prilocaine and the second one containing 4% liposomal lidocaine, in the treatment of vascular lesion during cosmetic dermatologic procedures.
Ten healthy volunteers were enrolled in our department. They showed telangiectasias, measuring between 0.5 and 1 millimeter in diameter on their face and limbs. Five volunteers were randomized to receive topical 4% liposomal lidocaine and five to receive 2.5% lidocaine and 2.5% prilocaine. In all treated areas, the 4% liposomal lidocaine was left for at least 30 minutes and the 2.5% lidocaine and 2.5% prilocaine was left for at least 60 minutes.
Clinically, the volunteers who received the 4% liposomal lidocaine showed minimal vasoconstrictor difference between before and after treatment; while the others who received the 2.5% lidocaine and 2.5% prilocaine showed a major vasoconstrictor effect. Furthermore the 4% liposomal lidocaine cream has the advantage of an anesthetic effect after 30 minutes, rather than 60 minutes for the 2.5% lidocaine and 2.5% prilocaine cream.
This study demonstrated that the 4% liposomal lidocaine has relatively minor vasoconstrictor effect when compared to the other anesthetic, and it shows how this type of anesthetic allows a clear vision of the lesion during the dermatologic procedures. Furthermore, this cream achieves an anesthetic effect in 30 minutes rather than the 60 minutes required for the other cream, making the first one more suitable for cosmetic dermatologic procedures and for the emergency.
本研究旨在评估两种最常用的局部麻醉剂的血管收缩作用，第一种含有 2.5%利多卡因和 2.5%丙胺卡因的混合物，第二种含有 4%脂质体利多卡因，用于治疗美容皮肤科手术中的血管病变。
我们部门招募了 10 名健康志愿者。他们的面部和四肢有直径在 0.5 至 1 毫米之间的毛细血管扩张症。5 名志愿者随机接受 4%脂质体利多卡因治疗，5 名志愿者接受 2.5%利多卡因和 2.5%丙胺卡因治疗。在所有治疗区域，4%脂质体利多卡因至少保留 30 分钟，2.5%利多卡因和 2.5%丙胺卡因至少保留 60 分钟。
临床观察发现，接受 4%脂质体利多卡因治疗的志愿者治疗前后血管收缩差异最小；而接受 2.5%利多卡因和 2.5%丙胺卡因治疗的志愿者则表现出明显的血管收缩作用。此外，4%脂质体利多卡因乳膏具有 30 分钟后起效的麻醉优势，而 2.5%利多卡因和 2.5%丙胺卡因乳膏则需要 60 分钟。
本研究表明，4%脂质体利多卡因的血管收缩作用相对较小，与其他麻醉剂相比，它显示了这种类型的麻醉剂如何在皮肤科手术中清晰地观察病变。此外，这种乳膏在 30 分钟内即可达到麻醉效果，而其他乳膏则需要 60 分钟，因此前者更适合美容皮肤科手术和急诊。
