野生苦瓜改善代谢综合征：初步饮食补充试验。
Wild bitter gourd improves metabolic syndrome: a preliminary dietary supplementation trial.
机构信息
Department of Family Medicine, Cheng Ching Hospital, Taichung 407, Taiwan.
出版信息
Nutr J. 2012 Jan 13;11:4. doi: 10.1186/1475-2891-11-4.
BACKGROUND
Bitter gourd (Momordica charantia L.) is a common tropical vegetable that has been used in traditional or folk medicine to treat diabetes. Wild bitter gourd (WBG) ameliorated metabolic syndrome (MetS) in animal models. We aimed to preliminarily evaluate the effect of WBG supplementation on MetS in Taiwanese adults.
METHODS
A preliminary open-label uncontrolled supplementation trial was conducted in eligible fulfilled the diagnosis of MetS from May 2008 to April 2009. A total of 42 eligible (21 men and 21 women) with a mean age of 45.7 ± 11.4 years (23 to 63 years) were supplemented with 4.8 gram lyophilized WBG powder in capsules daily for three months and were checked for MetS at enrollment and follow-up monthly. After supplementation was ceased, the participants were continually checked for MetS monthly over an additional three-month period. MetS incidence rate were analyzed using repeated-measures generalized linear mixed models according to the intention-to-treat principle.
RESULTS
After adjusting for sex and age, the MetS incidence rate (standard error, p value) decreased by 7.1% (3.7%, 0.920), 9.5% (4.3%, 0.451), 19.0% (5.7%, 0.021), 16.7% (5.4%, 0.047), 11.9% (4.7%, 0.229) and 11.9% (4.7%, 0.229) at visit 2, 3, 4, 5, 6, and 7 compared to that at baseline (visit 1), respectively. The decrease in incidence rate was highest at the end of the three-month supplementation period and it was significantly different from that at baseline (p = 0.021). The difference remained significant at end of the 4th month (one month after the cessation of supplementation) (p = 0.047) but the effect diminished at the 5th and 6th months after baseline. The waist circumference also significantly decreased after the supplementation (p < 0.05). The WBG supplementation was generally well-tolerated.
CONCLUSION
This is the first report to show that WBG improved MetS in human which provides a firm base for further randomized controlled trials to evaluate the efficacy of WBG supplementation.
背景
苦瓜（Momordica charantia L.）是一种常见的热带蔬菜，传统或民间医学常用来治疗糖尿病。野生苦瓜（WBG）可改善代谢综合征（MetS）的动物模型。我们旨在初步评估 WBG 补充剂对台湾成年人 MetS 的影响。
方法
一项初步的开放标签非对照补充试验于 2008 年 5 月至 2009 年 4 月期间在符合 MetS 诊断标准的合格患者中进行。共有 42 名符合条件的患者（21 名男性和 21 名女性）入组，平均年龄为 45.7 ± 11.4 岁（23 至 63 岁），每天服用 4.8 克冻干 WBG 粉末胶囊，持续三个月，并在入组时和每月随访时检查 MetS。补充剂停止后，参与者在额外的三个月内每月继续检查 MetS。根据意向治疗原则，使用重复测量广义线性混合模型分析 MetS 发生率。
结果
在调整性别和年龄后，MetS 的发生率（标准误差，p 值）分别下降了 7.1%（3.7%，0.920）、9.5%（4.3%，0.451）、19.0%（5.7%，0.021）、16.7%（5.4%，0.047）、11.9%（4.7%，0.229）和 11.9%（4.7%，0.229），分别在第 2、3、4、5、6 和 7 次访视时与基线（第 1 次访视）相比。在三个月的补充期结束时，发病率下降幅度最大，与基线相比差异有统计学意义（p = 0.021）。在第 4 个月结束时（补充停止后一个月）（p = 0.047）仍有显著差异，但在基线后第 5 和 6 个月时效果减弱。腰围在补充后也显著减小（p < 0.05）。WBG 补充剂通常耐受性良好。
结论
这是第一项表明 WBG 改善了人类 MetS 的报告，为进一步评估 WBG 补充剂的疗效提供了坚实的随机对照试验基础。
Zotero 插件