Electroanalytical Chemistry Research Laboratory, Faculty of Chemistry, University of Mazandaran, Babolsar, Iran.
Bioelectrochemistry. 2012 Jun;85:44-9. doi: 10.1016/j.bioelechem.2011.11.010. Epub 2011 Dec 7.
The electrocatalytic oxidation of amoxicillin was investigated on a nickel-based (Ni(II)-curcumin) chemically modified electrode. This modified electrode was prepared by electropolymerization of complex (curcumin = 1,7-bis[4-hydroxyl-3-methoxyphenyl]-1,6-heptadiene-3,5-dione) in alkaline solution. For the first time, the catalytic oxidation of amoxicillin was demonstrated by cyclic voltammetry, chronoamperometry, chronocoulometry and amperometry methods at the surface of this modified carbon paste electrode. The obtained results showed that NiOOH acts as an electrocatalyst for oxidation of amoxicillin. This electrocatalytic oxidation exhibited a good linear response for amoxicillin concentration over the range of 8 × 10⁻⁶-1×10⁻⁴ M with a detection limit of 5 × 10⁻⁶ M. Therefore, this electrocatalytic method was used as a simple, selective and rapid method able to determine amoxicillin in pharmaceutical preparations and biological media.
采用电化学聚合的方法，在镍基（Ni(II)-姜黄素）化学修饰电极上制备了姜黄素配合物（姜黄素=1,7-双[4-羟基-3-甲氧基苯基]-1,6-庚二烯-3,5-二酮），并研究了阿莫西林在该修饰电极上的电催化氧化行为。首次采用循环伏安法、计时安培法、计时库仑法和安培法在该修饰碳糊电极表面对阿莫西林的催化氧化进行了研究。结果表明，NiOOH 对阿莫西林的氧化具有电催化作用。该电催化氧化对阿莫西林浓度在 8×10⁻⁶-1×10⁻⁴ M 范围内表现出良好的线性响应，检测限为 5×10⁻⁶ M。因此，该电催化方法可作为一种简单、选择性和快速的方法，用于测定药物制剂和生物介质中的阿莫西林。
