BHF Glasgow Cardiovascular Research Centre, Institute of Cardiovascular and Medical Sciences, College of Medical, Veterinary, and Life Sciences, University of Glasgow, Glasgow, UK.
Microcirculation. 2012 Apr;19(3):196-207. doi: 10.1111/j.1549-8719.2012.00161.x.
Vascular endothelial cells derived from human pluripotent stem cells have substantial potential for the development of novel vascular therapeutics and cell-based therapies for the repair of ischemic damage. To gain maximum benefit from this source of cells, a complete understanding of the changes in gene expression and how they are regulated is required. miRNAs have been demonstrated to play a critical role in controlling stem cell pluripotency and differentiation and are important for mature endothelial cell function. Specific miRNAs that determine stem cell fate have been identified for a number of different cell lineages; however, in the case of differentiation and specification of vascular endothelial cells, this is yet to be fully elucidated.
人多能干细胞衍生的血管内皮细胞在新型血管治疗药物和基于细胞的治疗缺血性损伤的修复方面具有很大的潜力。为了从这种细胞来源中获得最大的益处，需要充分了解基因表达的变化及其调控方式。miRNAs 已被证明在控制干细胞多能性和分化方面发挥着关键作用，对于成熟内皮细胞的功能也很重要。已经确定了许多不同细胞谱系中决定干细胞命运的特定 miRNAs；然而，在血管内皮细胞的分化和特化方面，这方面的研究还尚未完全阐明。
