REBIRTH Research Group Reprogramming, Hannover Medical School 30625, Hannover, Germany.
J Mol Med (Berl). 2012 Jul;90(7):747-52. doi: 10.1007/s00109-012-0922-z. Epub 2012 Jun 9.
With the groundbreaking work of Takahashi and Yamanaka, induced pluripotent stem cells (iPSCs) have taken the stage of international stem cell research as a novel source of pluripotent cells and an alternative to embryonic stem cells (ESCs). Apart from their enormous potential as a starting source for the generation of patient-specific cell therapy products, iPSCs also highlight the power of artificially modulating transcriptional networks to induce dramatic changes of cell specification. Since small non-coding RNAs play important roles in the modulation and fine-tuning of transcriptional networks, microRNAs also exhibit important functions in directing cell fate decisions. In this review, we will discuss the role of microRNAs in pluripotent stem cells and their impact on the induction of pluripotency during reprogramming of somatic cells.
随着高桥和山中伸弥的开创性工作，诱导多能干细胞（iPS 细胞）作为多能细胞的新来源和胚胎干细胞（ES 细胞）的替代物，已经登上了国际干细胞研究的舞台。除了作为产生患者特异性细胞治疗产品的起始来源的巨大潜力外，iPS 细胞还突出了人为调节转录网络以诱导细胞特性剧烈变化的能力。由于小非编码 RNA 在调节和微调转录网络中发挥着重要作用，miRNA 在指导细胞命运决定方面也发挥着重要作用。在这篇综述中，我们将讨论 miRNA 在多能干细胞中的作用及其在体细胞重编程过程中诱导多能性中的影响。
