GGZ inGeest/Department of Psychiatry, Valeriusplein 9, Amsterdam, The Netherlands.
J Affect Disord. 2012 Mar;137(1-3):146-50. doi: 10.1016/j.jad.2011.12.035. Epub 2012 Jan 13.
Psychomotor symptoms are putative distinguishing features of melancholia that may guide treatment decisions. Hence, there is a need for valid instruments to assess psychomotor symptoms. The objective of this study is to examine the construct validity of the CORE, an observational instrument designed to quantify psychomotor symptoms in depression.
Associations between CORE scores and levels of motor activity measured by accelerometry were examined in a sample of 25 elderly depressed in-patients, for various time intervals, during 24h of follow-up.
Total CORE scores (as well as CORE retardation and agitation sub-scale scores) were negatively correlated with activity scores, with depression severity increasing the correlational strength substantively. For total CORE scores and retardation sub-scale scores, the highest associations were quantified across morning intervals.
Given the nature of the study mild levels of depression were overrepresented, monitoring of motor activity lasted only 24h and non-motor activity items in the CORE were not measured.
Associations between CORE total scores and retardation sub-scale scores support the validity of the CORE as well as quantifying associations between severity of psychomotor disturbance and clinical depression severity. Study results also support the application of accelerometry tools in quantifying components of clinical depression.
精神运动症状是忧郁症的假定特征，可能指导治疗决策。因此，需要有效的工具来评估精神运动症状。本研究的目的是检验 CORE 的构念效度，这是一种旨在量化抑郁症精神运动症状的观察工具。
在 25 名老年住院抑郁症患者中，在 24 小时随访期间的各个时间间隔内，检查 CORE 评分与加速度计测量的运动活动水平之间的关联。
总 CORE 评分（以及 CORE 迟缓和激动亚量表评分）与活动评分呈负相关，抑郁严重程度实质性地增加了相关性强度。对于总 CORE 评分和迟滞亚量表评分，最高的关联是在早晨间隔内量化的。
鉴于研究的性质，轻度抑郁程度占主导地位，运动活动监测仅持续 24 小时，CORE 中的非运动活动项目未被测量。
CORE 总分和迟滞亚量表评分之间的关联支持 CORE 的有效性，并量化了精神运动障碍严重程度与临床抑郁症严重程度之间的关联。研究结果还支持使用加速度计工具来量化临床抑郁症的各个组成部分。
