1Department of Biomedical Sciences,Collaborative Antwerp Psychiatric Research Institute (CAPRI),University of Antwerp,Antwerpen,Belgium.
3Translational Research Center,University Hospital of Psychiatry,University of Bern,Bern,Switzerland.
Acta Neuropsychiatr. 2018 Dec;30(6):359-364. doi: 10.1017/neu.2018.21. Epub 2018 Jul 30.
To explore the correlations between observer ratings and instrumental parameters across domains of psychomotor functioning in depression.
In total, 73 patients with major depressive disorder underwent extensive psychomotor and clinical testing. Psychomotor functioning was assessed with (i) an observer-rated scale (the CORE measure) and also objectively with (ii) 24-h actigraphy, and (iii) a fine motor drawing task.
Observer ratings of retardation correlated with instrumental assessments of fine and gross motor functioning. In contrast, observer ratings of agitation did not correlate with observer ratings of retardation or with the instrumental measures. These associations were partly influenced by age and, to a lesser extent, by depression severity.
Psychomotor disturbance is a complex concept with different manifestations in depressed patients. Although observer ratings of retardation correspond well with instrumental measures of the motor domains, objective measurement of agitation and other aspects of psychomotor disturbance require further research.
探索抑郁患者精神运动功能各领域中观察者评分与仪器参数之间的相关性。
共有 73 名重度抑郁症患者接受了广泛的精神运动和临床测试。精神运动功能评估采用（i）观察者评定量表（CORE 量表），以及（ii）24 小时活动记录仪和（iii）精细运动绘图任务进行客观评估。
观察者评定的迟滞与精细和粗大运动功能的仪器评估相关。相比之下，观察者评定的激越与观察者评定的迟滞或仪器测量值没有相关性。这些关联部分受到年龄的影响，在较小程度上受到抑郁严重程度的影响。
精神运动障碍是一个复杂的概念，在抑郁患者中有不同的表现。尽管迟滞的观察者评分与运动领域的仪器测量值很好地对应，但激越和其他精神运动障碍方面的客观测量需要进一步研究。
