Department of Corporal Expression, Faculty of Education, University of Cordoba, Córdoba, Spain.
Public Health Nutr. 2012 Oct;15(10):1827-34. doi: 10.1017/S1368980011003533. Epub 2012 Jan 16.
To assess classical and non-classical metabolic risk biomarkers in prepubertal children with different levels of cardiorespiratory fitness (CRF).
CRF was assessed by the 20 m shuttle run test. To estimate physical activity, participants were observed while engaged in an after-school programme. Additionally, a short test based on a validated questionnaire was used to obtain information about physical activity practice and sedentary habits. Anthropometric parameters, blood pressure, and classical and non-traditional metabolic risk biomarkers--plasma lipid profile, glucose and insulin, homeostasis model assessment-insulin resistance index (HOMA-IR), plasma uric acid, transaminases and C-reactive protein (CRP)--were measured.
The study was conducted in local elementary schools in Córdoba, Spain.
One hundred and forty-one healthy children (eighty-eight boys, fifty-three girls) aged 7-12 years, in Tanner stage I, were recruited. They were divided into two groups after they performed the 20 m shuttle run test: equal or higher cardiovascular fitness (EHCF) group and low cardiovascular fitness (LCF) group.
The LCF group displayed significantly higher TAG (P = 0.004) and lower HDL cholesterol levels (P = 0.001), as well as significantly lower values for the non-traditional lipid marker apo-A1 (P = 0.001) compared with the EHCF group. The LCF children displayed higher plasma glucose (P = 0.003) and insulin levels, higher HOMA-IR scores (P < 0.001) and higher plasma uric acid and CRP levels (P < 0.05). After adjustment for BMI, age and sex, no statistically significant differences were found between groups for the biomarkers analysed.
The study provides new information to understand the role not only of weight status but also of the level of CRF on the metabolic health profile of prepubertal children.
评估不同心肺功能（CRF）水平的青春期前儿童的经典和非经典代谢风险生物标志物。
CRF 通过 20 米穿梭跑测试进行评估。为了估计体力活动，观察参与者在课后活动中的表现。此外，还使用了一个基于经过验证的问卷的简短测试来获取有关体力活动实践和久坐习惯的信息。测量了人体测量参数、血压以及经典和非传统代谢风险生物标志物——血浆脂质谱、血糖和胰岛素、稳态模型评估胰岛素抵抗指数（HOMA-IR）、血浆尿酸、转氨酶和 C 反应蛋白（CRP）。
该研究在西班牙科尔多瓦的当地小学进行。
招募了 141 名健康儿童（88 名男孩，53 名女孩），年龄为 7-12 岁，处于 Tanner 1 期。他们在完成 20 米穿梭跑测试后分为两组：心血管健康水平相等或更高（EHCF）组和心血管健康水平较低（LCF）组。
LCF 组的 TAG（P=0.004）显著升高，HDL 胆固醇水平（P=0.001）显著降低，以及非传统脂质标志物 apo-A1 显著降低（P=0.001）与 EHCF 组相比。LCF 儿童的血浆葡萄糖（P=0.003）和胰岛素水平较高，HOMA-IR 评分较高（P<0.001），血浆尿酸和 CRP 水平较高（P<0.05）。在调整 BMI、年龄和性别后，两组间分析的生物标志物无统计学差异。
该研究提供了新的信息，以了解体重状况以及 CRF 水平对青春期前儿童代谢健康状况的作用。
