新型生物制剂在妇科癌症治疗中的应用。

New biologic agents for the treatment of gynecologic cancers.

机构信息

Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Brigham and Women's Hospital, Boston, MA 02115, USA.

出版信息

Hematol Oncol Clin North Am. 2012 Feb;26(1):133-56. doi: 10.1016/j.hoc.2011.11.002.

DOI:10.1016/j.hoc.2011.11.002

PMID:22244666

Abstract

The discovery of new biologic targeted agents and appropriately matching them to specific gynecologic tumor types either based on histology or the genetic make-up of the cancer is an exciting new chapter in the treatment of gynecologic malignancies. Therapeutic targets of multiple pathways are currently in study, and combinations with chemotherapy as well as combinations of pathway inhibitors are currently in development.

摘要

新的生物靶向药物的发现，以及根据组织学或癌症的遗传构成将它们与特定的妇科肿瘤类型相匹配，是妇科恶性肿瘤治疗的一个令人兴奋的新篇章。目前正在研究多种途径的治疗靶点，并且正在开发与化疗以及途径抑制剂组合的组合。