Medical Genetics, Molecular Medicine Centre, Institute of Genetics and Molecular Medicine, University of Edinburgh, Crewe Road South, Edinburgh, UK.
Neurosci Lett. 2012 Feb 21;510(1):6-9. doi: 10.1016/j.neulet.2011.12.059. Epub 2012 Jan 8.
Variation in the complement receptor 1 gene (CR1) has been identified in recent genome-wide association studies as a risk factor for Alzheimer's disease. Here, we show that two Alzheimer's disease-associated CR1 variants, rs6656401 and rs3818361, are associated with major recurrent depression in females in a population-based cohort using individuals from the Generation Scotland: Scottish Family Health Study.
最近的全基因组关联研究发现，补体受体 1 基因（CR1）的变异是阿尔茨海默病的一个风险因素。在这里，我们使用来自苏格兰世代研究：苏格兰家庭健康研究的个体，在一个基于人群的队列中表明，两个与阿尔茨海默病相关的 CR1 变体 rs6656401 和 rs3818361 与女性的主要复发性抑郁症有关。
