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补体受体 1 基因多态性与散发性阿尔茨海默病易感性在白种人群中的相关性：一项荟萃分析。

Complement receptor 1 genetic polymorphism contributes to sporadic Alzheimer's disease susceptibility in Caucasians: a meta-analysis.

机构信息

Department of Rehabilitation Medicine, The Second People's Hospital of Hefei City, Hefei, China.

出版信息

Biosci Rep. 2020 Jun 26;40(6). doi: 10.1042/BSR20200321.

DOI:10.1042/BSR20200321
PMID:32432316
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7268259/
Abstract

Complement receptor 1 (CR1) plays an important role in the development of sporadic Alzheimer's disease (SAD) in Caucasians. However, the influence of CR1 (rs6656401A/G and rs3818361T/C) genetic polymorphisms on the risk of SAD remains controversial. A meta-analysis of 18 case-control studies was performed to derive a more precise association of CR1 (rs6656401A/G or rs3818361T/C) genetic polymorphism with the risk of SAD in Caucasians. A statistical difference was found in the dominant model (odds ratio (OR): 1.23, 95% confidence interval (CI): 1.16-1.30, P=0.00), recessive model (OR: 1.28, 95% CI: 1.05-1.56, P=0.02), homozygote comparison (OR: 1.36, 95% CI: 1.12-1.66, P=0.002) or heterozygote comparison (AG versus GG) (OR: 1.21, 95% CI: 1.15-1.29, P=0.00) of CR1 rs6656401A/G. For CR1 rs3818361T/C, a statistical difference was observed in the dominant model (OR: 1.21, 95% CI: 1.13-1.31, P=0.00), recessive model (OR: 1.28, 95% CI: 1.07-1.53, P=0.006), homozygote comparison (OR: 1.35, 95% CI: 1.13-1.62, P=0.001) or heterozygote comparison (TC versus CC) (OR: 1.20, 95% CI: 1.11-1.29, P=0.00). In summary, despite some limitations, the present meta-analysis indicated that rs6656401A/G or rs3818361T/C polymorphism was related to SAD risk. Moreover, a carrier of rs6656401A/G or T carrier of rs3818361T/C in CR1 genetic polymorphism might be an increased factor for SAD in Caucasians.

摘要

补体受体 1（CR1）在白种人散发型阿尔茨海默病（SAD）的发病机制中发挥重要作用。然而，CR1（rs6656401A/G 和 rs3818361T/C）遗传多态性对 SAD 风险的影响仍存在争议。对 18 项病例对照研究进行了荟萃分析，以更精确地评估 CR1（rs6656401A/G 或 rs3818361T/C）遗传多态性与白种人 SAD 风险的相关性。在显性模型（比值比（OR）：1.23，95%置信区间（CI）：1.16-1.30，P=0.00）、隐性模型（OR：1.28，95%CI：1.05-1.56，P=0.02）、纯合子比较（OR：1.36，95%CI：1.12-1.66，P=0.002）或杂合子比较（AG 与 GG）（OR：1.21，95%CI：1.15-1.29，P=0.00）中，CR1 rs6656401A/G 存在统计学差异。对于 CR1 rs3818361T/C，在显性模型（OR：1.21，95%CI：1.13-1.31，P=0.00）、隐性模型（OR：1.28，95%CI：1.07-1.53，P=0.006）、纯合子比较（OR：1.35，95%CI：1.13-1.62，P=0.001）或杂合子比较（TC 与 CC）（OR：1.20，95%CI：1.11-1.29，P=0.00）中存在统计学差异。综上所述，尽管存在一定局限性，但本荟萃分析表明 rs6656401A/G 或 rs3818361T/C 多态性与 SAD 风险相关。此外，CR1 基因多态性中 rs6656401A/G 的携带者或 rs3818361T/C 的携带者可能是白种人 SAD 的一个危险因素。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8ac6/7268259/6bdbf1be98ea/bsr-40-bsr20200321-g9.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8ac6/7268259/c7f6580da096/bsr-40-bsr20200321-g8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8ac6/7268259/6bdbf1be98ea/bsr-40-bsr20200321-g9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8ac6/7268259/dfe7e23c44d7/bsr-40-bsr20200321-g1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8ac6/7268259/7ca83bcc119e/bsr-40-bsr20200321-g2.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8ac6/7268259/75c698c6537c/bsr-40-bsr20200321-g4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8ac6/7268259/c086f8e050d2/bsr-40-bsr20200321-g5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8ac6/7268259/afc5db666177/bsr-40-bsr20200321-g7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8ac6/7268259/c7f6580da096/bsr-40-bsr20200321-g8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8ac6/7268259/6bdbf1be98ea/bsr-40-bsr20200321-g9.jpg

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