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Oxidative stress and endosome recycling are complementary mechanisms reorganizing the T-cell receptor signaling complex in SLE.

作者信息

Perl Andras

出版信息

Clin Immunol. 2012 Mar;142(3):219-22. doi: 10.1016/j.clim.2011.12.011. Epub 2011 Dec 30.

DOI:10.1016/j.clim.2011.12.011
PMID:22245265
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4048946/
Abstract
摘要

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本文引用的文献

1
Linker for activation of T cells is displaced from lipid rafts and decreases in lupus T cells after activation via the TCR/CD3 pathway.T 细胞激活衔接蛋白在通过 TCR/CD3 途径激活后从脂筏中移位，并且在狼疮 T 细胞中减少。
Clin Immunol. 2012 Mar;142(3):243-51. doi: 10.1016/j.clim.2011.12.010. Epub 2011 Dec 30.
2
A negatively charged domain of LAT mediates its interaction with the active form of Lck.LAT的一个带负电荷的结构域介导其与Lck活性形式的相互作用。
Mol Membr Biol. 2011 Oct-Nov;28(7-8):487-94. doi: 10.3109/09687688.2011.624990.
3
mTOR signaling: a central pathway to pathogenesis in systemic lupus erythematosus?mTOR信号传导：系统性红斑狼疮发病机制的核心途径？
Discov Med. 2010 Mar;9(46):173-8.
4
Spleen tyrosine kinase: an Src family of non-receptor kinase has multiple functions and represents a valuable therapeutic target in the treatment of autoimmune and inflammatory diseases.脾酪氨酸激酶：一种非受体Src 家族激酶，具有多种功能，是治疗自身免疫性和炎症性疾病的有价值的治疗靶点。
Autoimmunity. 2010 Feb;43(1):48-55. doi: 10.3109/08916930903374717.
5
T-cell and B-cell signaling biomarkers and treatment targets in lupus.狼疮中的T细胞和B细胞信号生物标志物及治疗靶点。
Curr Opin Rheumatol. 2009 Sep;21(5):454-64. doi: 10.1097/BOR.0b013e32832e977c.
6
Activation of mammalian target of rapamycin controls the loss of TCRzeta in lupus T cells through HRES-1/Rab4-regulated lysosomal degradation.雷帕霉素哺乳动物靶蛋白的激活通过HRES-1/Rab4调节的溶酶体降解控制狼疮T细胞中TCRζ的丢失。
J Immunol. 2009 Feb 15;182(4):2063-73. doi: 10.4049/jimmunol.0803600.
7
T cell activation.T细胞活化。
Annu Rev Immunol. 2009;27:591-619. doi: 10.1146/annurev.immunol.021908.132706.
8
Differential expression and molecular associations of Syk in systemic lupus erythematosus T cells.系统性红斑狼疮T细胞中Syk的差异表达及分子关联
J Immunol. 2008 Dec 1;181(11):8145-52. doi: 10.4049/jimmunol.181.11.8145.
9
Metabolic control of T cell activation and death in SLE.系统性红斑狼疮中T细胞活化与死亡的代谢调控
Autoimmun Rev. 2009 Jan;8(3):184-9. doi: 10.1016/j.autrev.2008.07.041. Epub 2008 Aug 21.
10
PP2A dephosphorylates Elf-1 and determines the expression of CD3zeta and FcRgamma in human systemic lupus erythematosus T cells.蛋白磷酸酶2A使Elf-1去磷酸化，并决定人类系统性红斑狼疮T细胞中CD3ζ和FcRγ的表达。
J Immunol. 2008 Sep 1;181(5):3658-64. doi: 10.4049/jimmunol.181.5.3658.