Myhrer T, Iversen E G
Norwegian Defence Research Establishment, Division for Environmental Toxicology, Kjeller.
Brain Res Bull. 1990 Aug;25(2):293-8. doi: 10.1016/0361-9230(90)90074-a.
In a previous study, it was shown that the lateral entorhinal cortex (LEC) in the left hemisphere contains higher concentration of glutamate than in the right hemisphere. The purpose of the present study was to examine potential relationship between this neurochemical asymmetry and behavior. Rats with either left, right, or bilateral transections of the fiber connections between the temporal cortex and LEC were tested for postoperative retention of a visual discrimination task. Because histological verification of lesions was crucial in this study, analyses of neurochemistry had to be omitted. The results showed that both left and bilateral lesions resulted in impaired retention, but the bilateral group was even more impaired than the left group. The rats with lesions in the right hemisphere, however, used fewer trials to reach the learning criterion than the control group, but they did not make fewer errors than the controls. The results are discussed in terms of lateralization of mnemonic processes.
在先前的一项研究中发现，左半球的外侧内嗅皮层（LEC）中的谷氨酸浓度高于右半球。本研究的目的是检验这种神经化学不对称与行为之间的潜在关系。对颞叶皮层和LEC之间纤维连接进行左、右或双侧横断的大鼠进行视觉辨别任务的术后记忆保持测试。由于在本研究中病变的组织学验证至关重要，因此不得不省略神经化学分析。结果表明，左侧和双侧损伤均导致记忆保持受损，但双侧损伤组比左侧损伤组受损更严重。然而，右半球有损伤的大鼠达到学习标准所需的试验次数比对照组少，但它们犯的错误并不比对照组少。从记忆过程的侧化角度对结果进行了讨论。
