Myhrer T
Norwegian Defence Research Establishment, Division for Environmental Toxicology, Kjeller.
Exp Brain Res. 1991;84(3):517-24. doi: 10.1007/BF00230963.
It has previously been shown that the temporal and entorhinal cortices may be critically involved in memory. In Experiment 1, rats with either damage to the temporal cortex (TC), lateral entorhinal cortex (LEC), or the medial entorhinal cortex (MEC) were tested for retention of a preoperatively acquired simultaneous brightness discrimination task. TC and LEC lesions impaired retention, whereas MEC lesions were without mnemonic effect. In Experiment 2, rats with either disruptions of the anterior neural connections of TC (TC/Ant), posterior connections of TC (TC/Post), or conjoint disruptions (Ant/Post) were tested for retention of the visual discrimination task. TC/Ant and Post/Ant lesions resulted in relatively mild, but significant memory impairment, whereas a profound effect was seen after TC/Post lesions. The results are discussed in terms of a very important role for LEC and its connections with TC in mnemonic function.
先前的研究表明，颞叶皮质和内嗅皮质可能在记忆中起着关键作用。在实验1中，对颞叶皮质（TC）、外侧内嗅皮质（LEC）或内侧内嗅皮质（MEC）受损的大鼠进行测试，以检测其对术前习得的同时亮度辨别任务的记忆保持情况。TC和LEC损伤会损害记忆保持，而MEC损伤则没有记忆效应。在实验2中，对TC的前神经连接中断（TC/Ant）、TC的后神经连接中断（TC/Post）或联合中断（Ant/Post）的大鼠进行视觉辨别任务的记忆保持测试。TC/Ant和Post/Ant损伤导致相对较轻但显著的记忆损害，而TC/Post损伤后则出现了严重的影响。根据LEC及其与TC的连接在记忆功能中的非常重要的作用对结果进行了讨论。
