MR Research Facility, Department of Radiology, Wayne State University, HUH-MR Research G030/Radiology, 3990 John R Road, Detroit, MI 48201, USA.
Neuroimage. 2012 Aug 15;62(2):923-9. doi: 10.1016/j.neuroimage.2012.01.020. Epub 2012 Jan 8.
The development of functional brain magnetic resonance imaging (fMRI) has been a boon for neuroscientists and radiologists alike. It provides for fundamental information on brain function and better diagnostic tools to study disease. In this paper, we will review some of the early concepts in high resolution gradient echo imaging with a particular emphasis on susceptibility weighted imaging (SWI) and MR angiography (MRA). We begin with the history of our own experience in this area, followed by a discussion of the role of high resolution in studying the vasculature of the brain and how this relates to the BOLD (blood oxygenation level dependent) signal. We introduce the role of SWI and susceptibility mapping (SWIM) in fMRI and close with recommendations for future high resolution experiments.
功能磁共振成像（fMRI）的发展对神经科学家和放射科医生来说都是一个福音。它提供了有关大脑功能的基本信息，并为研究疾病提供了更好的诊断工具。在本文中，我们将回顾高分辨率梯度回波成像的一些早期概念，特别强调磁化率加权成像（SWI）和磁共振血管造影（MRA）。我们从该领域自身经验的历史开始，然后讨论高分辨率在研究大脑血管中的作用，以及如何与血氧水平依赖（BOLD）信号相关。我们介绍了 SWI 和磁化率图（SWIM）在 fMRI 中的作用，并对未来的高分辨率实验提出了建议。
