Siden E J, Baltimore D, Clark D, Rosenberg N E
Cell. 1979 Feb;16(2):389-96. doi: 10.1016/0092-8674(79)90014-x.
The majority of cell lines derived by infection of murine bone marrow cells with Abelson murine leukemia virus (A-MuLV) synthesize a mu chain but no detectable light chain. Aside from this mu-only phenotype, lines that make only light chain, both chains or no immunoglobulin-related polypeptides have also been found. Two lines have been studied in detail: one that makes only mu chain and one that makes only kappa light chain. Synthesis of both polypeptides can be increased by modifying the culture conditions so as to decrease the growth rate of the cells. Although some kappa chain secretion was observed, neither secreted nor surface mu was detected. We suggest that the mu- only phenotype may be an early normal step in the pathway of B lymphocyte maturation.
通过用阿贝尔森鼠白血病病毒（A-MuLV）感染鼠骨髓细胞衍生的大多数细胞系合成μ链，但未检测到轻链。除了这种仅合成μ链的表型外，还发现了仅合成轻链、同时合成两条链或不合成免疫球蛋白相关多肽的细胞系。对两个细胞系进行了详细研究：一个仅合成μ链，另一个仅合成κ轻链。通过改变培养条件以降低细胞生长速率，可以增加这两种多肽的合成。虽然观察到了一些κ链分泌，但未检测到分泌型或表面型μ链。我们认为，仅合成μ链的表型可能是B淋巴细胞成熟途径中的一个早期正常步骤。
