N-杂环卡宾介导的一锅法氢酰化- Sonogashira/Heck/Suzuki 偶联反应：一种新的级联反应。
N-heterocyclic carbene-mediated hydroacylation-Sonogashira/Heck/Suzuki coupling in a single pot: a new cascade reaction.
机构信息
Custom Pharmaceutical Services, Dr Reddy's Laboratories Limited, Bollaram Road, Miyapur, Hyderabad, 500 049, India.
出版信息
Org Biomol Chem. 2012 Feb 28;10(8):1670-9. doi: 10.1039/c2ob06950d. Epub 2012 Jan 16.
PMID:22246347
Abstract
A dually NHC-catalyzed reaction cascade comprising an initial hydroacylation of an activated ketone and subsequent Sonogashira/Heck/Suzuki coupling in the same pot is reported. The reaction mechanism and scope of the methodology is presented.
摘要
本文报道了一种双 NHC 催化的反应级联反应，包括在同一锅中对活化酮的初始氢酰化反应和随后的 Sonogashira/Heck/Suzuki 偶联反应。介绍了反应机理和方法的适用范围。
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