Organisch-Chemisches Institut, Westfälische Wilhelms-Universität Münster, Corrensstrasse 40, 48149 Münster, Germany.
Angew Chem Int Ed Engl. 2011 Dec 23;50(52):12626-30. doi: 10.1002/anie.201106155. Epub 2011 Nov 4.
Faster, higher, stronger! The N-heterocyclic carbene (NHC) catalyzed diastereo- and enantioselective hydroacylation of cyclopropenes affords structurally valuable acylcyclopropanes. A new family of electron-rich, 2,6-dimethoxyphenyl-substituted NHCs induces excellent reactivity and enantioselectivity. Preliminary kinetic studies unambiguously demonstrated the superiority of this family of catalysts over known NHCs in this challenging transformation.
更快、更高、更强！N-杂环卡宾（NHC）催化的环丙烯顺式和对映选择性氢甲酰化反应得到了具有结构价值的酰基环丙烷。一类新型富电子、2,6-二甲氧基苯基取代的 NHC 诱导出优异的反应活性和对映选择性。初步的动力学研究明确证明了该类催化剂在这一具有挑战性的转化中优于已知的 NHC。
